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Mount Sinai study identifies 20 new genetic associations with bipolar disorder

In the largest study of its kind, involving more than 50,000 subjects in 14 countries, researchers at the Icahn School of Medicine at Mount Sinai and more than 200 collaborating institutions have identified 20 new genetic associations with one of the most prevalent and elusive mental illnesses of our time--bipolar disorder.
Tags: Health, Mount Sinai, Icahn School of Medicine


Older kidney disease patients starting dialysis die at higher rates than previously thought

Older adults with end-stage kidney disease who start dialysis--a treatment that keeps their blood free of toxins--appear to die at higher rates than previously thought, according to findings of a new study by researchers at Harvard Medical School, Brigham and Women's Hospital, Veterans Affairs Boston Healthcare System and Icahn School of Medicine at Mount Sinai, among other institutions.
Tags: Health, Mount Sinai, Icahn School of Medicine, Harvard Medical School Brigham, Hospital Veterans Affairs Boston Healthcare System


New AI platform detects neurodegenerative diseases in brain tissue samples

Researchers have developed an artificial intelligence platform to detect a range of neurodegenerative disease in human brain tissue samples, including Alzheimer's disease and chronic traumatic encephalopathy, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published in the Nature medical journal Laboratory Investigation.
Tags: Health, Mount Sinai, Icahn School of Medicine


Mount Sinai awarded $12.5 million NIH grant for research program in aging biology

Researchers from the Icahn School of Medicine at Mount Sinai have been awarded a $12.5 million grant from the National Institute on Aging, part of the National Institutes of Health, for a five-year program called the U19 that consists of four multidisciplinary projects in aging biology.
Tags: Health, Mount Sinai, Icahn School of Medicine


Prior dengue virus infection increases Zika virus-induced damage during pregnancy

Women who have previously been infected with dengue virus may be at risk for increased damage to their fetuses and placentas if they should later become infected with the Zika virus, researchers from the Department of Microbiology at the Icahn School of Medicine at Mount Sinai report.
Tags: Health, Mount Sinai, Zika, Icahn School of Medicine, Department of Microbiology


New prostate cancer prediction tool has unmatched accuracy

A team of researchers from the Icahn School of Medicine at Mount Sinai and Keck School of Medicine at the University of Southern California have developed a novel machine-learning framework that distinguishes between low- and high-risk prostate cancer with more precision than ever before.
Tags: Health, University Of Southern California, Mount Sinai, Icahn School of Medicine, Keck School of Medicine


Mount Sinai joins with Paradigm and ReqMed to repurpose drug for treatment of MPS

The Icahn School of Medicine at Mount Sinai has entered into two exclusive licenses to develop the drug pentosan polysulfate sodium for and ReqMed Company, Ltd. of Japan.
Tags: Health, Mount Sinai, Icahn School of Medicine, ReqMed Company Ltd


Whole genome study identifies genetic architecture for diagnosis of polycystic ovary syndrome

In the largest genetic analysis of polycystic ovary syndrome (PCOS) performed to date, an international consortium, including researchers at the Icahn School of Medicine at Mount Sinai, conducted a whole genome association study to identify common genetic architecture for different diagnostic criteria used to define the syndrome.
Tags: Health, Mount Sinai, Icahn School of Medicine


Mount Sinai researcher awarded $2.5 million to advance understanding of neurodegenerative diseases

Ivan Marazzi, PhD, Assistant Professor of Microbiology at the Icahn School of Medicine at Mount Sinai, was awarded $2.5 million in funding by the Chan Zuckerberg Initiative to further the understanding of the underlying causes of neurodegenerative disorders such as Lou Gehrig's, Alzheimer's, and Parkinson's diseases. The
Tags: Health, Chan Zuckerberg Initiative, Mount Sinai, Lou Gehrig, Icahn School of Medicine, Ivan Marazzi


Study evaluates second-hand marijuana smoke exposure among children

In a study designed to evaluate second-hand marijuana smoke exposure among children--a topic that scientists have not yet widely addressed--researchers at the Icahn School of Medicine at Mount Sinai found that nearly half of children whose parents smoked marijuana showed evidence of second-hand marijuana smoke exposure.
Tags: Health, Mount Sinai, Icahn School of Medicine


Researchers develop tool that speeds up analysis and publication of biomedical data

Researchers at the Icahn School of Medicine at Mount Sinai have developed a tool that speeds up the analysis and publication of biomedical data from many months or years to mere minutes, transforming the way researchers communicate results of their studies.
Tags: Health, Mount Sinai, Icahn School of Medicine


Psychology Around the Net: November 3, 2018

This week’s Psychology Around the Net takes a look at what your reaction to WiFi failure says about your personality, the psychology of faking your own death, why reading could be the key to breaking free from chronic loneliness (and all the health risks loneliness brings), and more. ‘Darkitecture’: The Art and Psychology of Haunted House Design: Did you visit any haunted houses for Halloween, or maybe plan to this weekend? If you’re lucky (i.e. want the potentially scariest experience possible...
Tags: Psychology, UK, Mount Sinai, Icahn School of Medicine, Knox College, Frank T McAndrew, Seaver Autism Center for Research and Treatment


Researchers find key differences in brains of males and females with schizophrenia

Researchers from the Icahn School of Medicine at Mount Sinai have found clear disparities in the way males and females--both those with schizophrenia and those who are healthy--discern the mental states of others.
Tags: Health, Mount Sinai, Icahn School of Medicine


Lifespan vs. healthspan: "I'LL do it" mnemonic

Epigenetics"Tthere is nobody who disputes that epigenetics predicts life span”. Aging eight or more years faster than your calendar age equates to twice the typical risk of dying, while aging seven years slower is associated with half the risk of death, Horvath says."Life span predictor" clockHis lab has developed a "life span predictor" they named it after the Grim Reaper: DNAm GrimAge. The epigenetic clock is more accurate the younger a person is. It’s especially inaccurate for the very old. “...
Tags: Health, Facebook, New York City, Lifestyle, Mount Sinai, Icahn School of Medicine, Horvath, Ves Dimov, Geriatrics, Diane Meier


Researchers design modeling system to infer relationships between genes, drugs, and their environment

A team of researchers at the Icahn School of Medicine at Mount Sinai and the University of Washington has designed a modeling system that integrates genomic and temporal information to infer causal relationships between genes, drugs, and their environment, allowing for a more accurate prediction of their interactions over time.
Tags: Health, Mount Sinai, University of Washington, Icahn School of Medicine


TEAD1 protein appears to be important regulator of tumor migration in glioblastoma

A specific protein called TEAD1 is an important regulator of tumor migration in glioblastoma, the most common brain tumor in adults, and deactivating this protein may stop tumor cells from migrating away from the main tumor mass, according to research conducted at the Icahn School of Medicine at Mount Sinai and published October 1 in the journal Nature Communications.
Tags: Health, Mount Sinai, Icahn School of Medicine


Study offers solid link between visceral organs and brain’s reward, motivation system

A novel gut-to-brain neural circuit establishes the vagus nerve as an essential component of the brain system that regulates reward and motivation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published September 20 in the journal Cell.
Tags: Health, Mount Sinai, Icahn School of Medicine


Study: Women exposed to trauma in their lives gave birth to underweight male infants

In the first study of its kind, researchers from the Icahn School of Medicine at Mount Sinai have found significantly lower birth weights in male infants--an average decrease of 38 grams, or approximately 1.3 ounces--born to women who had been exposed to trauma at some point in their lives and who secreted higher levels of cortisol, a hormone related to stress, in late pregnancy.
Tags: Health, Mount Sinai, Icahn School of Medicine


NIH grant for Mount Sinai to study use of inhaled corticosteroids for treatment of sickle cell disease

The Departments of Emergency Medicine and Hematology at the Icahn School of Medicine at Mount Sinai have been awarded a $4 million grant from the National Institutes of Health toward further study of inhaled corticosteroids to treat sickle cell disease in individuals who do not have asthma.
Tags: Health, National Institutes of Health, Nih, Mount Sinai, Icahn School of Medicine, Emergency Medicine and Hematology


AI platform identifies acute neurological illnesses faster than human diagnosis

An artificial intelligence platform designed to identify a broad range of acute neurological illnesses, such as stroke, hemorrhage, and hydrocephalus, was shown to identify disease in CT scans in 1.2 seconds, faster than human diagnosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published today in the journal Nature Medicine.
Tags: Health, Mount Sinai, Icahn School of Medicine


Researchers report unusually high levels of herpesvirus in the brains of people with Alzheimer's disease

Two strains of human herpesvirus-;human herpesvirus 6A (HHV-6A) and human herpesvirus 7 (HHV-7) -;are found in the brains of people with Alzheimer's disease at levels up to twice as high as in those without Alzheimer's, researchers from the Icahn School of Medicine at Mount Sinai report.
Tags: Health, Mount Sinai, Icahn School of Medicine


Study finds elevated risk of congenital defects in lithium-exposed infants

Researchers from the Icahn School of Medicine at Mount Sinai found an elevated risk of major congenital malformations in fetuses after first-trimester exposure to lithium, in the largest study ever to examine the risk of birth defects in lithium-exposed babies.
Tags: Health, Mount Sinai, Icahn School of Medicine


Specific impairments within six large-scale brain networks linked to drug addiction behaviors

Specific impairments within six large-scale brain networks during drug cue exposure, decision-making, inhibitory control, and social-emotional processing are associated with drug addiction behaviors, according to a systematic review of more than 100 published neuroimaging studies by experts at the Icahn School of Medicine at Mount Sinai and published Wednesday, June 6 in the journal Neuron.
Tags: Health, Mount Sinai, Icahn School of Medicine


Novel microscope technology offers images of the brain with 4K resolution and 3D visualization

The Department of Neurosurgery at the Icahn School of Medicine at Mount Sinai is one of the first hospitals in the country to use the ZEISS KINEVO 900 microscope, a new surgeon-driven, robotic visualization system that merges the functionality of a surgical microscope with 4K resolution and 3D visualization along with specialized robotic control.
Tags: Health, Mount Sinai, Icahn School of Medicine, Department of Neurosurgery


Zinc and copper metabolism in baby teeth may help predict ASD risk

Using evidence found in baby teeth, researchers from the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai report that cycles involved in zinc and copper metabolism are dysregulated in autism spectrum disorder, and can be used to predict who will later develop the disease.
Tags: Health, Mount Sinai, Icahn School of Medicine


Scientists find overlap between causes of RA and Huntington’s disease

Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans.
Tags: Health, Mount Sinai, HUNTINGTON, Icahn School of Medicine


Researchers discover significant distortions in leading genetics study method

Many conclusions drawn from a common approach to the study of human genetics could be distorted because of a previously overlooked phenomenon, according to researchers at the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai and collaborators from Massachusetts General Hospital and the Broad Institute.
Tags: Health, Mount Sinai, Massachusetts General Hospital, Icahn School of Medicine, Department of Genetics and Genomics Sciences


New initiative launched to support goals of Human Cell Atlas

Uri Laserson, PhD, Assistant Professor in the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai, and collaborators have been awarded one of 85 grants announced today from the Chan Zuckerberg Initiative DAF (CZI), an advised fund of Silicon Valley Community Foundation.
Tags: Health, Mount Sinai, Icahn School of Medicine, Uri Laserson, Department of Genetics and Genomics Sciences


Repeated anesthesia in early life increases anxiety-linked behaviors, animal study shows

Rhesus macaques repeatedly exposed to anesthesia during infancy display persistent anxiety-linked behaviors later in life in response to social stress, a study from Yerkes National Primate Research Center at Emory University and Icahn School of Medicine at Mount Sinai shows.
Tags: Health, Mount Sinai, Emory University, Icahn School of Medicine, Yerkes National Primate Research Center


Novel grape-derived compounds could be developed as therapeutic agents for treatment of depression

In a study to be published online February 2 in Nature Communications, scientists from the Icahn School of Medicine at Mount Sinai describe an extensive analysis of novel grape-derived compounds, dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc),which might be developed as therapeutic agents for the treatment of depression.
Tags: Health, Mount Sinai, Nature Communications, Icahn School of Medicine



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