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Physicians graduated outside the U.S. offer better care for Medicare patients with complex needs

A study by a Massachusetts General Hospital research team indicates that internal medicine physicians who are graduates of medical schools outside the U.S. care for Medicare patients with more complex medical needs than those cared for by graduates of American medical schools.
Tags: Health, Medicare, Massachusetts General Hospital


Research reveals critical immunological axis that triggers cancer-promoting chronic inflammation

A Massachusetts General Hospital research team has identified interaction between two elements of the immune system as critical for the transformation of a protective immune response into chronic, cancer-promoting inflammation.
Tags: Health, Massachusetts General Hospital


Brain-zapping implants that change mood and lift depression

Teams of researchers are developing sesame seed-size neuro-implants that detect brain activity that signals depression and then deliver targeted electrical zaps to elevate your mood. It's very early days in the science and technology but recent studies suggest that we're on the path. Links to scientific papers below. Fortunately, the goal is to develop tools and a methodology more precise than the horrifically blunt "shock therapy" of last century. From Science News: DARPA, a Department of...
Tags: Post, Science, News, Minneapolis, Neuroscience, Department Of Defense, Mental Health, Depression, Darpa, Brains, Ucla, Massachusetts General Hospital, UCSF, University of Minnesota, Justin Sanchez, Widge


The cause of Alzheimer’s may be gum disease

Bacteria in periodontitis seems to be the culprit. Reported amyloid and tau buildups may be a response, not a cause. Compelling research offers a genuine reason for optimism. Dementia is now the fifth leading cause of death around the world, and 70 percent of that is due to Alzheimer's disease. Until now, experts have been baffled by what causes it, and powerless at slowing or reversing the cruel progress of this condition. Alzheimer's pulls its victims away from reality as their families watch...
Tags: Health, Discovery, Bacteria, Brain, Innovation, Disease, Dementia, Microbes, Massachusetts General Hospital, Melbourne Australia, Alzheimer, University of Central Lancashire, Moir, Casey Lynch, Cortexyme, Alzheimer's science


Hypertension drug may improve effectiveness of ovarian cancer treatment

A new study from a Massachusetts General Hospital research team has found that the hypertension drug losartan, which targets the angiotensin signaling pathway, may improve the effectiveness of chemotherapy agents used to treat ovarian cance
Tags: Health, Massachusetts General Hospital


Study finds specific function of HIV protein that slows viral spread in early stages of infection

A study from a Massachusetts General Hospital research team has identified the specific function of a protein found in HIV and related viruses that appears to slow down viral spread in the earliest stages of infection.
Tags: Health, Massachusetts General Hospital


MGH-led research team reveals how solid stress impacts tissue surrounding brain tumors

A Massachusetts General Hospital-led research team has demonstrated, for the first time, how solid stress - the physical forces exerted by the solid components of a tumor - impacts the tissue surrounding brain tumors and contributes to resulting neurological dysfunction and neuronal cell death.
Tags: Health, Massachusetts General Hospital, MGH


Three studies examine readiness of U.S. emergency departments to care for children

Three papers from research teams led by a Massachusetts General Hospital physician examine the current readiness of U.S. emergency departments to care for children and describe an initiative that led to the appointment of a Pediatric Emergency Care Coordinator - a step considered the single best intervention to improve pediatric emergency care - in all Massachusetts EDs.
Tags: Health, Massachusetts, Massachusetts General Hospital, Pediatric Emergency Care Coordinator


Tau protein reduces neural activity in Alzheimer's mouse models

A study from Massachusetts General Hospital investigators sheds new light on how the hallmarks of Alzheimer's disease - amyloid-beta (A-beta) plaques and neurofibrillary tangles containing the protein tau - produce their damaging effects in the brain.
Tags: Health, Massachusetts General Hospital


New mouse model shows potential for rapid identification of promising muscular dystrophy therapies

A Massachusetts General Hospital research team has created a new mouse model of a common form of muscular dystrophy with the potential of rapidly distinguishing promising therapeutic drugs from those unlikely to be successful.
Tags: Health, Massachusetts General Hospital


Ezogabine treatment reduces motor neuron excitability in ALS patients, study shows

Brian Wainger, MD, PhD, of the Healey Center for ALS at Massachusetts General Hospital presented initial, top-level results of a recently completed phase 2 clinical trial of ezogabine (also called retigabine) on December 9 at the Motor Neurone Disease Association annual meeting in Glasgow, Scotland.
Tags: Health, Massachusetts General Hospital, Motor Neurone Disease Association, Brian Wainger, Healey Center


MGH researchers use advanced imaging technology to measure magnetite levels in the brain

Investigators at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital have used magnetoencephalography - a technology that measures brain activity by detecting the weak magnetic fields produced by the brain's normal electrical currents - to measure levels of the iron-based mineral called magnetite in the human brain.
Tags: Health, Massachusetts General Hospital, MGH, Martinos Center for Biomedical Imaging


Doctor no parents want to see is one they need when their children are dying

The doctor bends slightly at the waist, or he slouches, or he kneels, or he finds a chair to sink into, anything to get low. He wants to be physically beneath the devastated people he meets several times a day. They stand over him, looking back with such pleading in their eyes. He wants them to feel powerful and in control, when he knows at the moment they are meeting him, they feel none of those things. Glen Komatsu, MD, is the chief medical officer at Providence Trinity Health Care Hospice...
Tags: Health, Japan, News, Children, Congress, California, Boston, Sport, Indiana, Harvard, Soccer, United States, Hawaii, Ohio, Ivy League, University Of Arizona


New study does not support hypertensive effect from urate elevation

A study from a group of Massachusetts General Hospital investigators may reduce the concern that elevating levels of urate, an approach being investigated to treat several neurodegenerative disorders, could increase the risk of hypertension.
Tags: Health, Massachusetts General Hospital


Predictive model could improve sepsis care

Researchers from MIT and Massachusetts General Hospital have developed a predictive model that could guide clinicians in deciding when to give potentially life-saving drugs to patients being treated for sepsis in the emergency room.
Tags: Health, Mit, Massachusetts General Hospital


Targeting immune checkpoints in microglia could reduce out-of-control neuroinflammation

A group of Massachusetts General Hospital investigators is proposing that targeting immune checkpoints - molecules that regulate the activity of the immune system - in immune cells called microglia could reduce the inflammatory aspects of important neurodegenerative diseases like Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis.
Tags: Health, Massachusetts General Hospital


New automated model identifies dense breast tissue in mammograms

Researchers from MIT and Massachusetts General Hospital have developed an automated model that assesses dense breast tissue in mammograms -- which is an independent risk factor for breast cancer -- as reliably as expert radiologists.
Tags: Health, Mit, Massachusetts General Hospital


Researchers identify effective ketamine dosage levels for patients with treatment-resistant depression

A study led by Massachusetts General Hospital investigators identifies two subanesthetic dosage levels of the anesthetic drug ketamine that appear to provide significant symptom relief to patients with treatment-resistant depression.
Tags: Health, Massachusetts General Hospital


Microglia lead to increased neuro-inflammation in fibromyalgia patients, finds study

A study by Massachusetts General Hospital researchers - collaborating with a team at the Karolinska Institutet in Sweden - has documented for the first time widespread inflammation in the brains of patients with the poorly understood condition called fibromyalgia.
Tags: Health, Sweden, Massachusetts General Hospital, Karolinska Institutet


Urine exRNA may be source of biomarkers for muscular dystrophy

Massachusetts General Hospital researchers have found that extracellular RNA in urine may be a source of biomarkers for the two most common forms of muscular dystrophy, noninvasively providing information about whether therapeutic drugs are having the desired effects on a molecular level.
Tags: Health, Massachusetts General Hospital


New study describes effect of radiation exposure on hormone deficiency in children

In a new study, University of Cincinnati researchers, in collaboration with Massachusetts General Hospital, have detailed the effect of radiation exposure on the development of hormone deficiency in pediatric and young adult patients treated for brain tumors.
Tags: Health, Massachusetts General Hospital, University Of Cincinnati


5 reasons you should put physicians in charge of hospitals

Putting physicians in charge of hospitals seems like a no-brainer, but it isn’t what usually happens. A study published in Academic Medicine states that only about four percent of hospitals in the United States are run by physician leaders, which represents a steep decline from 35 percent in 1935. In the most recent 2018 Becker’s Hospital Review “100 Great Leaders in Healthcare,” only 29 are physicians. The stats don’t lie, however. Health care systems run by physicians do better. When comparing...
Tags: Health, United States, Practice Management, Massachusetts General Hospital, Becker, Physician, Hospital-Based Medicine, Hospital Review


MGH researchers explore how genetic abnormality in Ewing sarcoma unleashes tumor growth

A Massachusetts General Hospital research team has used epigenome editing tools to investigate how the genetic abnormality that drives Ewing sarcoma - the second most common bone cancer in children and young adults - unleashes tumor growth.
Tags: Health, Massachusetts General Hospital, Ewing, MGH


New mouse model shows great promise for Rett syndrome research

In an article released today from Jeannie T. Lee, MD PhD of Massachusetts General Hospital, there is hope on the horizon for future research specific to Rett syndrome, a rare childhood neurodevelopmental disorder.
Tags: Health, Massachusetts General Hospital, Jeannie T Lee


Study finds mechanism by which amyloid beta protects the brain from herpes infection

A Massachusetts General Hospital study has found the mechanism by which amyloid beta - the protein deposited into plaques in the brains of patients with Alzheimer's disease - protects from the effects of herpes viruses commonly found in the brain.
Tags: Health, Massachusetts General Hospital


Researchers use MR spectroscopy to investigate mechanisms behind targeted treatment for gliomas

Using a novel imaging method, a Massachusetts General Hospital research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas.
Tags: Health, Massachusetts General Hospital


OVARIES MAY MAKE NEW EGGS - EXTENDED FERTILITY

Pregnancy Over 40 and New Egg Supply I've written about this subject before, some studies suggest that there may be a way for the ovaries to replenish their egg supply. The current belief is that a woman is born with all the eggs she will ever have. Read more:Women may possess a hidden cache of stem cells in the bone marrow that constantly replenish the ovaries with new eggs, a new study suggests.The idea contradicts long-established scientific dogma that holds that a woman is born with ...
Tags: Health, Infertility, Massachusetts General Hospital, Sandy Robertson, Jonathan Tilly


Study finds neuroinflammation in spinal cord, nerve roots of patients with chronic sciatica

A study by Massachusetts General Hospital investigators has found, for the first time in humans, that patients with chronic sciatica - back pain that shoots down the leg - have evidence of inflammation in key areas of the nervous system.
Tags: Health, Massachusetts General Hospital


Researchers discover significant distortions in leading genetics study method

Many conclusions drawn from a common approach to the study of human genetics could be distorted because of a previously overlooked phenomenon, according to researchers at the Department of Genetics and Genomics Sciences at the Icahn School of Medicine at Mount Sinai and collaborators from Massachusetts General Hospital and the Broad Institute.
Tags: Health, Mount Sinai, Massachusetts General Hospital, Icahn School of Medicine, Department of Genetics and Genomics Sciences


MGH researchers identify risk factors for drug overdose in youth with substance use disorders

A team of Massachusetts General Hospital investigators has identified factors that may increase the risk of drug overdose in adolescents and young adults. In their report published online in the Journal of Clinical Psychiatry, the researchers describe finding that more than a quarter of those seeking treatment at Addiction Recovery Management Service, an MGH-based outpatient substance-use-disorder treatment program for youth ages 14 to 26, had a history of at least one overdose.
Tags: Health, Massachusetts General Hospital, MGH, Addiction Recovery Management Service



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