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Bio Roundup: Nationwide’s Rise, a Surgeon’s Quest, CRISPR USA & More

Persistence and perseverance were the themes of two of our top stories this week.First there’s the story of Nationwide Children’s Hospital. The Columbus, Ohio, hospital chose to invest in gene therapy when the field was in its darkest days. After some ups and downs, the team it put in place helped advance some of the most promising gene therapies currently in human testing—and put Nationwide in the national spotlight as one of those treatments nears FDA approval.Then there’s Suzanne Ildstad. A ...
Tags: Boston blog main, Boston top stories, Boulder/Denver blog main, Boulder/Denver top stories, Detroit blog main, Detroit top stories, Indiana blog main, Indiana top stories, National, National blog main, National top stories, New York blog main, New York top stories, Raleigh-Durham blog main, Raleigh-Durham top stories, San Diego blog main


$100M For Talaris Gives Surgeon a Shot to Reinvent Organ Transplants

When Novartis dissolved its gene and cell therapy unit a few years ago, a bunch of projects the Swiss pharma giant had incubated were tossed aside. One of them was the work of surgeon Suzanne Ildstad, who has spent decades trying to develop a new way to improve the health outcomes of patients who need organ transplants.That work has just been salvaged. If it plays out as Ildstad hopes, her company might not only help transform treatment for kidney failure patients—but possibly, for people suffe...
Tags: Deals, Startups, Boston, Trends, Vc, National Institutes of Health, Novartis, Stem Cell, Stanford University, Life Sciences, Blackstone Group, Louisville Ky, National blog main, New York blog main, New York top stories, Seattle blog main


Lyft, Uber, and the Changing Disclosure Rules For Unicorn IPOs

When a much-watched tech company such as Lyft, Uber, or Pinterest files for an initial public stock offering, people eagerly scour the sudden trove of information that such a private business must finally disclose when it begins to offer shares to the general public, rather than only to sophisticated inside investors such as venture capital firms.For newly public company Lyft, (NASDAQ: LYFT) though, the IPO disclosure requirements were significantly lower than they would usually be for business...
Tags: Deals, Startups, Transportation, Mobile, Lyft, Uber, Hardware, Pinterest, Internet, Entrepreneurship, Ipo, Funding, San Francisco, Trends, Tech, Financial Crisis


Thwarting Opposition, Bristol Gets Shareholder OK for $74B Celgene Buyout

The early opposition has turned out to be just noise. Shareholders of Bristol-Myers Squibb today approved the pharma giant’s planned buyout of Celgene, paving the way for a deal that will create one of the largest biopharma organizations in the world, and send ripples throughout the sector. (NYSE: BMY) said Friday that more than 75 percent of its shareholders voted to approve the deal at a meeting on Friday. Some 98 percent (NASDAQ: CELG) of Celgene’s stockholders supported the deal, the compa...
Tags: Deals, New York, Trends, Merck, M&a, Life Sciences, Nyse, Celgene, Bristol-myers Squibb, National blog main, New York blog main, New York top stories, Seattle blog main, Seattle top stories, Boston blog main, National top stories


VC Trends in 2019: More Money, Fewer Deals But Women Still Get Less

If you’ve been following venture capital trends, what you expected to happen in the first quarter of 2019 did: More money is being invested in fewer deals, and women founders still are getting less of it than men.Venture firms sent $32.6 billion into startups nationally during the first three months of 2019, the second largest amount for any quarter since at least 2006, according to data released overnight by PitchBook and the National Venture Capital Association. But that large sum came from o...
Tags: Deals, Startups, Lyft, Uber, Hardware, Entrepreneurship, Softbank, Funding, Women, Trends, Tech, Vc, Software, Physics, Pwc, Venture Capital


Bio Roundup: Gottlieb’s Goodbye, AACR Recap, Migraine Drug Fight & More

Scott Gottlieb’s last day as FDA commissioner is today. His resignation announcement last month surprised some, given the earlier denials about leaving. But after two years of commuting between Connecticut, where his family remained, and the FDA’s Maryland headquarters, he decided to step down from the agency.What will Gottlieb’s legacy be? His efforts to curb teen vaping comes to mind. Or maybe it’s regulation. While Gottlieb remained mindful of the FDA’s oversight role, he also tried to strea...
Tags: Deals, Startups, Maryland, Breast Cancer, Trends, Investing, Lung Cancer, Connecticut, Cigna, Venture Capital, Fda, National, Novartis, Pfizer, Biotech, Insulin


Bio Roundup: Amyloid Angst, NASH News, Brammer Bagged & More

A week after , the ripple effects are still being felt—and not just by Biogen, which lost billions of dollars in market value in a flash.We’ll kick off this week’s roundup with the aducanumab reaction, which includes plenty of thoughts about the future of the so-called “amyloid hypothesis” and what’s next for another Biogen Alzheimer’s drug that has had mixed results.We’ll also check in on the gene therapy deal spree, the big week in national healthcare policy, and the preparations several com...
Tags: Deals, Obamacare, Trends, Alzheimer's Disease, Affordable Care Act, National, Pfizer, Medicaid, Xarelto, Federal Trade Commission, Life Sciences, Bayer, Clinical Trials, Celgene, Gilead Sciences, Eisai


Lyft Raises $2.2B in IPO, Pegging Valuation at Over $24B

Investors eager to bet on the mobility industry’s future handed ride-hailing company Lyft $2.2 billion in new capital Thursday as the company completed an IPO that set its market capitalization at $24.3 billion, The New York Times reported.Lyft sold 30.8 million shares at $72 apiece, according to Renaissance Capital—the top of a new range that Lyft originally set at $62 to $68. The company was valued at $15.1 billion at the time of its last fundraising in mid-2018.Lyft’s pricey showing rivals A...
Tags: Deals, Startups, Mobile, Lyft, Uber, Hardware, Marketplace, Pinterest, Entertainment, Internet, Entrepreneurship, Funding, US, San Francisco, Trends, Tech


Bio Roundup: Golumbeski’s Legacy, CRISPR Moratorium, Rebate Week & More

While all eyes in the biopharmaceutical world are currently trained on Bristol-Myers Squibb’s proposal to buy Celgene for $74 billion, it wasn’t that long ago that another company’s gaze was fixed on the Summit, NJ, drug maker.In the early 2000s, before the FDA approved Celgene’s flagship multiple myeloma drug lenalidomide (Revlimid), Novartis (NYSE: NVS considered buying the company. It passed, unwilling to risk billions on an unapproved drug. Those details came from biopharma dealmaker George...
Tags: Deals, Startups, China, Ipo, Cancer, Trends, Investing, Merck, Colorectal Cancer, Multiple Sclerosis, Harvard University, Health Insurance, Astrazeneca, Center For Medicare And Medicaid Services, Fda, National


The Life, Troubles, and Celgene Legacy of Deal Guru George Golumbeski

George Golumbeski is one of the most prolific dealmakers in the biopharmaceutical world. But the deal that changed his life is a pact he made with himself when he was ten years old.Playing with friends in front of his house in Hampton, VA, he watched his mother drag his dead-drunk father, a U.S. Air Force veteran who did a short stint in Vietnam, out of his car. Pretending to sleep in his bedroom, he’d often hear his parents screaming at each other.“I can’t end up like this,” he remembers think...
Tags: Deals, Ipo, Events, Trends, People, Depression, National, Novartis, Vietnam, Biotech, Illumina, New Enterprise Associates, Life Sciences, University Of Wisconsin, Genentech, UCB


Bio Roundup: Pharma in DC, Bristol-Cel in Trouble, Roche Gets A Spark

Could a shareholder revolt doom the planned marriage of Bristol-Myers Squibb and Celgene? Analysts have hinted at the possibility since the two companies shook hands in January, but the threat became real this week.Bristol (NYSE: BMY) and Celgene (NASDAQ: CELG) have campaignned heavily, starting with a joint presentation by their CEOs at the J.P. Morgan Healthcare Conference in January. Celgene drugs that should come to market the next two years will unlock $15 billion in annual revenue. The co...
Tags: Deals, Startups, Ge, Trends, Merck, Vc, Astrazeneca, Fda, National, Bristol, Novartis, Pfizer, Life Sciences, Clinical Trials, Celgene, Amgen


Scaleworks Adds $80M for Second “Venture Equity” Investment Fund

San Antonio—[Updated 12:32 p.m. See below.] Scaleworks has raised $80 million to acquire more startups, three years after Lew Moorman and Ed Byrne founded the business as a “venture equity” investment shop.Scaleworks branded its investment style as a mix of private equity and venture capital because it buys its targets outright like a private equity shop and will invest additional capital if needed to help a business grow, like a VC firm. The San Antonio company has been buying software-as-a-se...
Tags: Apple, Deals, Google Drive, Cloud, Facebook, Texas, Microsoft, Developer, Cloud Computing, Disney, Sale, Trends, Investing, Development, It, Vc


Bio Roundup: NASH News, Merck Strikes, Digital Tokens & More

The growing epidemic of the fatty liver disease known as NASH, which has no FDA-approved treatment, has led to a frenzied race among drug companies. This week, one company, Intercept Pharmaceuticals, solidified its lead. But how much will being first to the finish line mean when all is said and done?Intercept (NASDAQ: ICPT) reported interim data from a Phase 3 study showing its drug, obeticholic acid (OCA), reduced liver scarring in NASH patients. The results should be enough to support an appr...
Tags: Deals, Startups, Drugs, Cancer, Trends, Investing, Merck, Leukemia, Acne, Inflammatory Bowel Disease, Xerox, Astrazeneca, Fda, National, Pfizer, Abbvie


Foot Traffic Startup Scraffic Mulls New Funding, Machine Learning

San Antonio—Scraffic, a small startup that helps retailers count foot traffic in their stores, has gone international.The San Antonio-based business, which has four employees, now has customers in the Philippines, Spain, Portugal, and Canada, as well as users in the U.S. Scraffic found opportunity to expand in international markets like the Philippines because there are fewer competitors, says Ryan Ward, Scraffic’s chief operating officer. Founded in 2016, the company’s price point helped, too:...
Tags: Startups, Texas, Technology, Shopping, Trends, Startup, Tech, Spain, Software, Camera, Canada, Philippines, Portugal, Retail, Machine Learning, Software Development


Bio Roundup: Alzheimer’s Fail, Drug Price Plan, Gene Therapies & More

Pharmaceutical companies typically raise prescription drug prices at the start of each year and this year was no different. The increases were the latest reminder that, despite President Trump’s fiery campaign rhetoric, the administration had done little to actually lower drug prices. But a new plan aimed at the secretive rebate deals between pharma companies and pharmacy benefit managers could change things.Insurers, or their intermediaries, negotiate with pharma companies for pricing discount...
Tags: Deals, Startups, Ipo, Cancer, Trends, Investing, Alzheimer's Disease, Chuck Grassley, Medicare, SEC, National, Novartis, Pfizer, Parkinson's Disease, Biotech, Vaccines


Equidate, Re-Named Forge Global, Boosts Series B to $85M

Equidate, one of the trading platforms that help employees sell their shares in pre-IPO unicorn companies, rolled out a new name today and announced a $35 million expansion of its $50 million funding round publicized in July.Re-branded as Forge Global, the five-year-old company plans to continue broadening the services it developed as many venture capital-backed companies—“unicorns” already supposedly worth billions of dollars, at least on paper—delayed going public, even while some of their st...
Tags: Deals, Startups, Lyft, Uber, Spotify, Spacex, Pinterest, Entrepreneurship, Ipo, Funding, San Francisco, Trends, Tech, Snapchat, Vc, Dropbox


CommonGrounds Raises $100M to Open More New Flexible Office Spaces

Billions of dollars have already flowed to the purveyors of shared workspaces, and the investment spigot isn’t turning off yet.CommonGrounds Workspace, a San Diego, CA-based company that operates flexible office spaces in California and Colorado today, announced Wednesday that it had raised $100 million in a Series A financing to expand its lineup to roughly 50 sites during the next two years.The company says the new money comes from three investors: CommonGrounds’s seed-stage backer, a local r...
Tags: Deals, Facebook, Real Estate, Microsoft, Developer, Colorado, California, Funding, Trends, Tech, Nike, Development, Cigna, Venture Capital, San Diego, WeWork


Bio Roundup: #JPM19 Notes, Loxo Buyout, Black Diamond’s Cash & More

Diabetes drugs are Eli Lilly’s bread and butter, but the pharmaceutical giant hasn’t lost its appetite for cancer drugs. It grabbed hold of a few more this week by betting $8 billion on Loxo Oncology.Loxo (NASDAQ: LOXO) has made a name for itself by becoming one of just two companies ever to earn an FDA approval for a drug that targets a tumor’s DNA fingerprint, no matter where in the body that cancer is found. The drug, larotrectinib, targets rare tumor abnormalities known as NTRK fusions. The...
Tags: Deals, Startups, Ipo, Cancer, Trends, Medicare, SEC, Fda, National, GlaxoSmithKline, Allergan, Shire, Biotech, Medical Device, Postpartum Depression, Bernie Sanders


Online Tech Expands Cloud, Data Services with Neverfail Acquisition

Online Tech, the Ann Arbor, MI-based provider of cloud services, beefed up its capabilities last month when it acquired the infrastructure-as-a-service and data protection businesses of Neverfail, an IT company located in Austin, TX. The terms of the deal were not disclosed.Online Tech CEO Brad Cheedle says his company offers managed services around cloud computing. The company’s service include assessing if a customer is cloud-ready or migrating their data to the cloud, Cheedle says. “Companie...
Tags: Deals, Startups, Entrepreneurship, Cloud Computing, Trends, Tech, It, Software, Austin, Innovation, Data Protection, Detroit, Infrastructure As A Service, Ann Arbor, National blog main, Texas blog main


Big Deals, Life Sciences Push U.S. VC in 2018 to Dot-Com Boom Levels

Venture capital investments rose in 2018 to levels not seen since the heady days of 2000, the last year U.S. startups collectively took in more than $100 billion.That’s according to PitchBook and the National Venture Capital Association’s Venture Monitor report, released this week, which tallied nearly 9,000 deals made last year, through which venture investors sunk $130.9 billion into companies. That was about 500 fewer deals than in the year prior, but the total amount invested increased by $...
Tags: Deals, Startups, Lyft, Uber, Entrepreneurship, Funding, Trends, Vc, Software, Pwc, Venture Capital, Angel, National, WeWork, Magic Leap, Biotech


Microsoft, Kroger Advance Grocery Tech to Fend Off Amazon

From the cloud on down to the floors of supermarkets, the rivalry between Microsoft and Amazon spans many sectors in software, gadgets, and increasingly, retail.The Seattle-area tech giants are battling—both with one another, and other competitors—to further digitize grocery shopping. The latest salvo came on Monday from Microsoft (NASDAQ: MSFT), which announced new details of its partnership with Kroger (NYSE: KR), one of the leading grocery store chains in the U.S. The Cincinnati-based grocer...
Tags: Amazon, Deals, Microsoft, Whole Foods, Cloud Computing, Trends, Tech, Amazon Prime, Supermarkets, E-commerce, Software, Grocery Stores, Retail, Seattle, Cincinnati, Kroger


Bio-JPM Roundup: Lilly Buys Loxo, Sage’s Stock Soars, ALS Cash & More

The flow of biotech news is particularly heavy today, and for good reason. The annual J.P. Morgan Healthcare Conference, one of the biggest gatherings for the biopharmaceutical industry, kicked off today in San Francisco, and many companies, whether they’re speaking at the event or not, use this time to get their news out.Xconomy is on the ground covering the conference this week. In the meantime, here’s a short roundup of biotech news announced today.DEALS AND DATA—Eli Lilly (NYSE: LLY) is pay...
Tags: Deals, Startups, San Francisco, Trends, Investing, Vc, Venture Capital, Fda, National, GlaxoSmithKline, Biotech, Postpartum Depression, Life Sciences, Clinical Trials, Celgene, Gilead Sciences


From Alnylam to Zayner: Xconomy’s Top Innovation Stories of 2018

2018 was a year of ups and downs for the business and technology community. It was a year of big exits—both IPOs and acquisitions—for tech and life sciences companies. Venture funding remained strong, but more money went to fewer (and later-stage) companies overall. As the year winds down, we’re reflecting on the big innovation trends and developments that will carry over to next year.Storylines in various sectors helped shape the overall narrative in 2018. Cell and gene therapies, cancer immun...
Tags: Deals, Startups, Technology, Cloud Computing, Trends, Tech, IPOs, It, People, Cybersecurity, Analysis, Vc, Software, Bitcoin, Bill Gates, Innovation


CFOs: Prepare To Become Your Company’s Data Czar This Year

In mid-2018, Tom Bogan was the leader of business planning software company Adaptive Insights as it planned its own next steps. The Palo Alto, CA-based company was on the point of raising about $115 million in a June IPO that would have set its market value at around $705 million, according to PitchBook.But like Dustin Hoffman in “The Graduate,” the big enterprise software company Workday lured Adaptive Insights away from the IPO altar with a more attractive deal—a $1.55 billion acquisition off...
Tags: Deals, Startups, Cloud, Internet, Entrepreneurship, Ipo, Funding, San Francisco, Trends, Tech, Web, It, Excel, Software, Data Science, Innovation


RiverVest Venture Closes $184M Fund for Backing Healthcare Ventures

RiverVest Venture Partners, a St. Louis, MO-based venture capital firm with additional offices in San Diego, CA, and Cleveland, OH, has raised $184.4 million for its fourth fund dedicated to investing in healthcare companies.Since its launch, RiverVest has invested in 47 companies working to develop new drugs and medical devices. Nearly half of the businesses in its portfolio have either been acquired or gone public, according to RiverVest.Among the notable exits was San Diego’s Lumena Pharmace...
Tags: Deals, Money, Trends, Vc, Venture Capital, San Diego, Astrazeneca, Biotech, Medical Device, Life Sciences, Abbott Laboratories, San Diego CA, St Louis MO, Cleveland OH, Cambridge Associates, ZS Pharma


Pfizer, GSK to Merge Consumer Health Units, Focus on Prescription Drugs

Two of the world’s top drugmakers want to focus on making prescription drugs. Pfizer and GlaxoSmithKline have agreed to merge their consumer health businesses and spin them off into a joint venture, a move that will both create a new consumer healthcare giant and increase the pressure on each company to churn out innovative medicines.GSK (NYSE: GSK) will hold 68 percent of the new company, with Pfizer (NYSE: PFE) getting the remaining 32 percent. The combined company will have some $12.7 billio...
Tags: Deals, Drugs, Trends, National, GlaxoSmithKline, Novartis, Pfizer, Vaccines, Pharma, Life Sciences, GSK, National blog main, New York blog main, Seattle blog main, Boston blog main, National top stories


Graphcore Scores $200M to Scale Up A.I. Chip Production

One of the leading contenders in the A.I. chip race, Graphcore, announced Thursday it pulled down $200 million in a Series D fundraising round that set its valuation at $1.7 billion.The Bristol, UK-based startup, founded in 2016, has now secured a total of more than $300 million in financing from venture capital firms and other investors including Microsoft and the corporate venture arms of BMW and Dell Technologies.Graphcore’s big haul is a notable milestone in the recent revival of investor i...
Tags: Google, Deals, Startups, Facebook, Hardware, Microsoft, Internet, Entrepreneurship, Softbank, Funding, Samsung, San Francisco, Trends, Tech, It, Mit


Bio Roundup: Eli Lilly Tries Tau, Generic Insulin, NASH Cash & More

Pharmaceutical industry critics lament the cost of rare disease drugs, but some of the steepest price hikes have come on widely used insulin.The patent holder, the University of Toronto, gave companies the right to manufacture insulin. But the university also allowed them to patent the improvements they made, which enabled them to slap higher prices on each new version.In the nearly 100 years since insulin’s discovery, no generic version has become available in the U.S. to offer competitive pri...
Tags: Deals, Startups, Breast Cancer, Washington, Ipo, Cancer, Trends, Investing, Diabetes, Schizophrenia, Venture Capital, Addiction, Fda, National, Novartis, Biotech


Udacity Achieves 50,000 Nanodegree Grads Amid Company Reorganization

Udacity, a pioneer in the online teaching of IT skills, is celebrating a milestone today—50,000 students have now graduated from one of its revenue-generating “Nanodegree” programs.Launched four years ago, the Nanodegree courses allow students worldwide to gain expertise in areas such as data analytics, machine learning, and autonomous flight engineering by completing coursework that can take as little as six months.In a blogpost touting student successes, Udacity co-founder Sebastian Thrun (pi...
Tags: Google, Amazon, Deals, Startups, Mobile, Facebook, Lyft, Hardware, Talent Gap, Education, Microsoft, Workplace, Internet, Entrepreneurship, Funding, San Francisco


Female-Centric Coworking Firm The Riveter Raises $15M to Fuel Growth

The outlook appears to be rosy for The Riveter.The Seattle-based startup, which bills itself as a “membership network built by women, for everyone,” says it has raised $15 million in new funding.The Riveter, which launched in May 2017, operates coworking spaces and organizes events and workshops for its members and the public. It currently has three locations in its home city and two in Los Angeles, and plans to use some of the proceeds from the new funding round to expand to other parts of the...
Tags: Deals, Startups, California, Entrepreneurship, Los Angeles, Trends, Vc, WeWork, Seattle, Madrona Venture Group, Regus, PitchBook, JLL, National blog main, Seattle blog main, Seattle top stories



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