Posts filtered by tags: EBV[x]


 

A future mono vaccine may have a shot at defeating multiple sclerosis, a new study suggests

Particles of the mononucleosis virus (dark circles) inside a cell.CDC A study provides the strongest evidence to date suggesting the Epstein-Barr virus may lead to multiple sclerosis.  Scientists disagree about whether EBV definitively causes MS. Experts hope a vaccine may one day prevent some MS cases, but it may take decades. Scientists have found the strongest evidence to date that an infection from the Epstein-Barr virus could significantly increase the risk of developing multiple scleros...
Tags: UK, Science, News, Trends, Multiple Sclerosis, Harvard, News UK, National Institutes of Health, Vaccine, Thompson, University College London, Epidemiology, Epstein Barr, EBV, Harvard T H Chan School of Public Health, Alan Thompson


Multiple sclerosis may be caused by infection with the Epstein-Barr virus

Multiple sclerosis (MS), a progressive disease that affects 2.8 million people worldwide and for which there is no definitive cure, is likely caused by infection with the Epstein-Barr virus (EBV), according to a study led by Harvard T.H. Chan School of Public Health researchers.
Tags: Health, Epstein Barr, EBV, Harvard T H Chan School of Public Health


Epstein-Barr Virus Found To Trigger Multiple Sclerosis

An anonymous reader quotes a report from Scientific American: A connection between the human herpesvirus Epstein-Barr and multiple sclerosis (MS) has long been suspected but has been difficult to prove. Epstein-Barr virus (EBV) is the primary cause of mononucleosis and is so common that 95 percent of adults carry it. Unlike Epstein-Barr, MS, a devastating demyelinating disease of the central nervous system, is relatively rare. It affects 2.8 million people worldwide. But people who contract infe...
Tags: Tech, Stanford University, Epstein Barr, EBV, Epstein, Lawrence Steinman, William H Robinson, Alberto Ascherio


Long COVID and severe COVID-19 infections associated with Epstein-Barr virus reactivation

Two recently published studies indicate Epstein-Barr virus (EBV) reactivation may play a role both in the development of long COVID symptoms, as well as severe COVID-19 cases. A study in Pathogens found over 73% of COVID-19 patients who were experiencing long Covid symptoms were also positive for EBV reactivation. A study in Scientific Reports by Nature found EBV reactivation was also associated with COVID-19 severity.
Tags: Science, Epstein Barr, EBV


Epstein-Barr virus reactivation may be the cause of long COVID symptoms

Epstein-Barr virus (EBV) reactivation resulting from the inflammatory response to coronavirus infection may be the cause of previously unexplained long COVID symptoms -- such as fatigue, brain fog, and rashes -- that occur in approximately 30% of patients after recovery from initial COVID-19 infection.
Tags: Health, Epstein Barr, EBV


Long COVID symptoms likely caused by Epstein-Barr virus reactivation

Epstein-Barr virus (EBV) reactivation may be the cause of previously unexplained long COVID symptoms -- such as fatigue, brain fog, and rashes -- that occur in approximately 30% of patients after recovery from initial COVID-19 infection. The first evidence linking EBV reactivation to long COVID, as well as an analysis of long COVID prevalence, is outlined in a new long COVID study published in the journal Pathogens.
Tags: Science, Epstein Barr, EBV


HKBU develops dual-targeting drug for EBV-related cancers

A Hong Kong Baptist University-led (HKBU) research team has developed a novel drug which has the potential to become a next-generation treatment for cancers associated with Epstein-Barr virus (EBV).
Tags: Science, Epstein Barr, EBV, Hong Kong Baptist University, HKBU


Scientists make pivotal discovery on mechanism of Epstein-Barr virus latent infection

Wistar Researchers have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer. Study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers.
Tags: Science, Epstein Barr, EBV, Epstein Barr Virus EBV, Wistar Researchers


HKUMed develops a novel therapeutic approach against Epstein-Barr virus-associated tumours

A research team at LKS Faculty of Medicine, The University of Hong Kong (HKUMed) discovered that exosomes derived from Vδ2-T cells (Vδ2-T-Exos) can effectively control Epstein-Barr virus-associated tumours and induce T-cell anti-tumour immunity. The novel findings of Vδ2-T-Exos provide insights into new therapeutic approach for Epstein-Barr virus (EBV)-associated tumours. The ground-breaking findings have been published in the leading academic journal, Science Translational Medicine.
Tags: Science, Epstein Barr, EBV, Exos


EBV viral genome alters the host epigenetic landscape to drive stomach cancer

he Epstein-Barr virus (EBV), one of the most common human viruses, is associated with about 8-10 per cent of stomach -- or gastric -- cancers, the third leading cause of cancer death globally.
Tags: Health, Epstein Barr, EBV


Epstein-Barr virus rewires host epigenomes to drive stomach cancer

Researchers in Japan and Singapore have discovered a molecular mechanism that explains how Epstein-Barr virus (EBV) infection alters a host's epigenome to promote tumorigenesis (the transformation of normal cells into cancer cells) in certain types of stomach cancer. The findings suggest that EBV infection plays an important role in the development of EBV-associated stomach cancers, and provide fresh insights that may lead to new therapies for stomach and other virus-related malignancies.
Tags: Japan, Science, Singapore, Epstein Barr, EBV


Off-the-shelf EBV-specific T cell immunotherapy for rituximab-refractory EBV-associated lymphoma following transplantation

BACKGROUND Adoptive transfer of donor-derived EBV-specific cytotoxic T-lymphocytes (EBV-CTLs) can eradicate EBV-associated lymphomas (EBV-PTLD) after transplantation of hematopoietic cell (HCT) or solid organ (SOT) but is unavailable for most patients.METHODS We developed a third-party, allogeneic, off-the-shelf bank of 330 GMP-grade EBV-CTL lines from specifically consented healthy HCT donors. We treated 46 recipients of HCT (n = 33) or SOT (n = 13) with established EBV-PTLD, who had failed rit...
Tags: Richard, Nih, Rick, EBV, GMP, Memorial Sloan Kettering Cancer Center, SOT, Juliet Barker, Heather Landau, National Marrow Donor Program, Barbara Spitzer, Julie Teruya-Feldstein, Maria Arcila, Susan Prockop, Ekaterina Doubrovina, Stephanie Suser


Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia (XMEN) disease are caused by deficiency of the magnesium transporter 1 (MAGT1) gene. We studied 23 patients with XMEN, 8 of whom were EBV naive. We observed lymphadenopathy (LAD), cytopenias, liver disease, cavum septum pellucidum (CSP), and increased CD4–CD8–B220–TCRαβ+ T cells (αβDNTs), in addition to the previously described features of an inverted CD4/CD8 ratio, CD4+ T lymphocytopenia, increased B cells, dysgammagl...
Tags: Juan, EBV, CSP, Ping Jiang, Susan Price, Jeffrey I. Cohen, Les R. Folio, José Luis Franco, Harry L. Malech, Matthias Mann, Juan C. Ravell, Mami Matsuda-Lennikov, Samuel D. Chauvin, Juan Zou, Matthew Biancalana, Sally J. Deeb


XMEN: welcome to the glycosphere

XMEN (X-linked immunodeficiency with magnesium defect, EBV infection, and neoplasia) is a complex primary immunological deficiency caused by mutations in MAGT1, a putative magnesium transporter. In this issue of the JCI, Ravell et al. greatly expand the clinical picture. The authors investigated patients’ mutations and symptoms and reported distinguishing immunophenotypes. They also showed that MAGT1 is required for N-glycosylation of key T cell and NK cell receptors that can account for some of...
Tags: EBV, Xmen, Hudson H Freeze, JCI Ravell


11 Free Programs to Help Veterans Succeed as Entrepreneurs

Veteran-owned businesses are an important engine of economic growth. New research from Experian has found that veterans tend to own and operate business with a larger employee base, and veteran-owned businesses have better longevity and sustainability than non veteran-owned business. (Experian analyzed and compared the credit data of veteran-owned businesses and non-veteran-owned businesses from 2015 through July 2019.)  Nearly 25% of veterans express interest in starting a business. That...
Tags: Florida, Abc, Government, Sales, Veterans, United States, Va, University of Florida, Experian, Chattanooga, Ifa, Operations, EBV, SBA, University of Tennessee, Mississippi State University


Are we there yet? The never-ending quest for an Epstein-Barr virus vaccine

The Epstein-Barr virus (EBV) is estimated to infect a large part of the population and is associated with a variety of human tumors; therefore, EBV is an important target for vaccine development. In this issue of the JCI, Rühl et al. developed a promising heterologous prime-boost vaccination strategy for EBV-associated malignancies and symptomatic primary infection. The authors show that two prime-boost regimens, using either dendritic cells or an adenovirus approach targeting nuclear antigen EB...
Tags: Epstein Barr, EBV, Sandhya Sharma, Rayne H. Rouce, Ankara MVA, Sandhya Sharma Rayne H Rouce


Heterologous prime-boost vaccination protects against EBV antigen–expressing lymphomas

The Epstein-Barr virus (EBV) is one of the predominant tumor viruses in humans, but so far no therapeutic or prophylactic vaccination against this transforming pathogen is available. We demonstrated that heterologous prime-boost vaccination with the nuclear antigen 1 of EBV (EBNA1), either targeted to the DEC205 receptor on DCs or expressed from a recombinant modified vaccinia virus Ankara (MVA) vector, improved priming of antigen-specific CD4+ T cell help. This help supported the expansion and ...
Tags: Epstein Barr, EBV, MVA, Julia Rühl, Carmen Citterio, Christine Engelmann, Tracey Haigh, Andrzej Dzionek, Johannes Dreyer, Rajiv Khanna, Graham S. Taylor, Joanna B. Wilson, Carol S. Leung, Christian Münz, Ankara MVA


CD30: From witness to culprit

Cells of certain blood cancers such as Hodgkin's lymphoma carry the protein CD30 on their surface. The molecule is not only an indicator of a few cancers of the immune system but also increases the risk of their occurrence, according to a report in the journal Blood by researchers of the Helmholtz Zentrum München. A greatly increased number of CD30-bearing cells are produced after certain viral infections, e.g. Epstein-Barr virus (EBV) infection, and in autoimmune diseases.
Tags: Science, Epstein Barr, EBV, Hodgkin, Helmholtz Zentrum


Progress toward Epstein-Barr virus vaccine

A research team has determined how several antibodies induced by Epstein-Barr virus (EBV), a herpesvirus that causes infectious mononucleosis and is associated with certain cancers, block infection of cells grown in the laboratory. They then used this information to develop novel vaccine candidates that, in animals, elicited potent anti-EBV antibody responses that blocked infection of cell types involved in EBV-associated cancers.
Tags: Epstein Barr, EBV


NIH researchers make progress toward Epstein-Barr virus vaccine

A research team led by scientists from NIH's National Institute of Allergy and Infectious Diseases (NIAID) has determined how several antibodies induced by Epstein-Barr virus (EBV), a herpesvirus that causes infectious mononucleosis and is associated with certain cancers, block infection of cells grown in the laboratory. They then used this information to develop novel vaccine candidates that, in animals, elicited potent anti-EBV antibody responses that blocked infection of cell types involved i...
Tags: Nih, Epstein Barr, EBV


Small molecule inhibitors show treatment potential for EBV-associated cancers

Wistar researchers have created a drug candidate for cancers associated with Epstein-Barr Virus (EBV), the virus that causes infectious mononucleosis.
Tags: Science, EBV, Epstein Barr Virus


Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus [Microbiology]

Primary effusion lymphoma (PEL) is a B cell lymphoma that is always associated with Kaposi’s sarcoma-associated herpesvirus (KSHV) and in many cases also with Epstein–Barr virus (EBV); however, the requirement for EBV coinfection is not clear. Here, we demonstrate that adding exogenous EBV to KSHV+ single-positive PEL leads to increased...
Tags: Epstein Barr, EBV, Epstein, Barr, Kaposi, KSHV


Circular DNA tumor viruses make circular RNAs [Microbiology]

Epstein−Barr virus (EBV) and Kaposi’s sarcoma herpesvirus (KSHV) cause ∼2% of all human cancers. RNase R-resistant RNA sequencing revealed that both gammaherpesviruses encode multiple, uniquely stable, circular RNAs (circRNA). EBV abundantly expressed both exon-only and exon−intron circRNAs from the BamHI A rightward transcript (BART) locus (circBARTs) formed from a spliced...
Tags: EBV, Epstein, Kaposi, KSHV


Inherited p40phox deficiency differs from classic chronic granulomatous disease

Biallelic loss-of-function (LOF) mutations of the NCF4 gene, encoding the p40phox subunit of the phagocyte NADPH oxidase, have been described in only 1 patient. We report on 24 p40phox-deficient patients from 12 additional families in 8 countries. These patients display 8 different in-frame or out-of-frame mutations of NCF4 that are homozygous in 11 of the families and compound heterozygous in another. When overexpressed in NB4 neutrophil-like cells and EBV-transformed B cells in vitro, the muta...
Tags: EBV, PMA, DHR, Jacinta Bustamante, Laurent Abel, Jean-Laurent Casanova, Neil Warner, Peter D. Arkwright, Steven M. Holland, Helmut Wittkowski, Dirk Foell, Laura Perez, Douglas B. Kuhns, John I. Gallin, Annemarie van de Geer, Alejandro Nieto-Patlán


Experimental drug takes aim at cancers associated with Epstein-Barr virus

Epstein-Barr Virus (EBV) doesn't directly cause cancer, but infection with this common herpes virus brings an increased risk of some cancers, including fast-growing lymphomas. This week in mSphere, researchers report on a new drug that works by targeting EBV-positive tumors.
Tags: Epstein Barr, EBV, Epstein Barr Virus


STAT3 can be a therapeutic target for chronic active EBV infection, a fatal disorder

Chronic active Epstein-Barr virus infection (CAEBV) is an inflammatory disorder with potential for tumor development. Here, unusual phosphorylation was observed on STAT3 in EBV-infected T- or NK-cells from patients with CAEBV. Researchers found that ruxolitinib, a drug that is currently used for treatment of myelofibrosis and polycythemia vera, could suppress the survival of these EBV-infected cells in a dose-dependent manner, and that STAT3 could be an important new target for treatment of CAEB...
Tags: Epstein Barr, EBV


STAT3 can be a therapeutic target for chronic active EBV infection, a fatal disorder

Chronic active Epstein-Barr virus infection (CAEBV) is an inflammatory disorder with potential for tumor development. Here, unusual phosphorylation was observed on STAT3 in EBV-infected T- or NK-cells from patients with CAEBV. Tokyo Medical and Dental University(TMDU) researchers found that ruxolitinib, a drug that is currently used for treatment of myelofibrosis and polycythemia vera, could suppress the survival of these EBV-infected cells in a dose-dependent manner, and that STAT3 could be an ...
Tags: Science, Epstein Barr, EBV, Tokyo Medical and Dental University TMDU


A viral protein kinase drug target for tumors?

The human gammaherpesviruses, Epstein-Barr virus (EBV) and Kaposi’s sarcoma–associated herpesvirus (KSHV), are both associated with tumors. Standard antiviral therapies are ineffective at treating these tumors. A serine/threonine kinase important for viral replication is conserved across the herpesviruses. Expression of the KSHV protein kinase in transgenic mice under the control of a ubiquitin promoter was associated with B cell lymphoproliferative disease and lymphoma. If the viral protein kin...
Tags: Epstein Barr, EBV, Kaposi, KSHV, Richard F Ambinder


'Mono' virus linked to 7 serious diseases

The Epstein-Barr virus (EBV) -- best known for causing mononucleosis -- also increases the risks for some people of developing seven other major diseases, according to a study in Nature Genetics. The diseases are: systemic lupus erythematosus, multiple sclerosis, rheumatoid arthritis, juvenile idiopathic arthritis, inflammatory bowel disease, celiac disease, and type 1 diabetes. Combined, these diseases affect nearly 8 million people in the US.
Tags: Epstein Barr, EBV


Sick with worry. Pregnancy phobia and a weird period.

Hi everyone. I should preface this post by saying that I have an irrational pregnancy fear. I'm a hypochondriac in general who tends to do too much reading on the internet. I'm looking into some mental health counseling in the new year. I guess what I'm looking for is someone to tell me I'm overreacting. Anyway.Back in October I had a bartholin cyst turn into an abcess. The ER I went to lanced me in the wrong spot and I was in agony until my gyno appointment where I got lanced a second time. I w...
Tags: Sex, EBV