Posts filtered by tags: HCC[x]


 

Lilly's Cyramza Gets FDA Nod for Second-Line Liver Cancer

Lilly's (LLY) Cyramza gets FDA approval to treat AFP-high hepatocellular carcinoma (HCC), a common form of liver cancer. FDA removes boxed warning from label.
Tags: Science, Fda, Afp, Lilly, HCC


Percutaneous ablation vs. surgery for hepatocellular carcinoma

Compared to surgery, percutaneous liver ablation interventions (IRs) in patients with hepatocellular carcinoma (HCC) are associated with lower inhospital mortality, length of hospital stay (LOS), and hospitalization costs, according to a study to be presented at the ARRS 2019 Annual Meeting, set for May 5-10 in Honolulu, Hawaii.
Tags: HCC


Alentis Therapeutics raises 12.5 mln swiss francs

Alentis Therapeutics said April 30 that it completed a Series A financing round of 12.5 million swiss francs led by BioMedPartners and BB Pureos Bioventures. BPI France, Schroder Adveq and the German High-Tech Gründerfonds (HTGF) also participated in the round. Alentis is a Swiss-French biotech company developing therapeutics in advanced liver disease and cancer.   PRESS RELEASE   ALENTIS Therapeutics launches, raising CHF 12.5m in a Series A to develop novel therapeutics in advanced live...
Tags: France, Ipo, Germany, US, Trends, Dallas, Novartis, Sanofi, Alsace, CBO, Basel Switzerland, GE Healthcare, Markus, Strasbourg France, HCC, VC Deals


Watercraft, Events Exclusions Bar Coverage

    The Federal District Court for the District of Hawaii found bodily injury suffered in a boating accident was barred under the policy's Watercraft and Events Exclusions.  Great Divide Ins. Co. v. Hawaiian Kamali`i , 2019 U.S. Dist. LEXIS 43106 (D. Haw. March 15, 2019).     The Hawaiian Canoe Club (HCC) hosted and sponsored the 2016 Pailolo Challenge Outrigger Canoe Race on September 17, 2016, from Kapalua, Maui to Kaunakakai, Moloka`i. Mark Stevens agreed to provide and operate an escort boat...
Tags: Insurance, Hawaii, Steven, Stevens, Hawaii Supreme Court, HCC, Mark Stevens, Kobayashi, Ohana, Federal District Court, Kaunakakai, Comprehensive General Liability, Duty to Defend, Tred Eyerly, Kapalua Maui, Events Exclusions Great Divide Ins Co


Genes linked with the most common liver cancer

Researchers have provided the first summary of the experimental evidence supporting the AKR1B10 enzyme as a promising therapeutic target for Hepatocellular carcinoma (HCC), based on a review of more than 50 studies published since this gene was first identified and characterized in 1998.
Tags: HCC


TGen review links gene with the most common liver cancer

In an article published in the scientific journal Cancers, researchers at the Translational Genomics Research Institute (TGen), an affiliate of City of Hope, provide the first summary of the experimental evidence supporting the AKR1B10 enzyme as a promising therapeutic target for Hepatocellular carcinoma (HCC), based on a review of more than 50 studies published since this gene was first identified and characterized in 1998.
Tags: Science, TGen, Translational Genomics Research Institute TGen, HCC


Why men are more likely to develop liver cancer

Researchers have discovered that a hormone secreted by fat cells that is present at higher levels in women can stop liver cells from becoming cancerous. The study helps explain why hepatocellular carcinoma (HCC) is more common in men, and could lead to new treatments for the disease, which is the fourth leading cause of cancer-related death worldwide.
Tags: HCC


Researchers discover why men are more likely to develop liver cancer

Researchers in Spain have discovered that a hormone secreted by fat cells that is present at higher levels in women can stop liver cells from becoming cancerous. The study, which will be published April 3 in the Journal of Experimental Medicine, helps explain why hepatocellular carcinoma (HCC) is more common in men, and could lead to new treatments for the disease, which is the fourth leading cause of cancer-related death worldwide.
Tags: Spain, HCC


HCC to sell litigation claims to BlackRock-led investors

Hindustan Construction Company Ltd (HCC) said on Tuesday it would sell rights to a portfolio of awards and claims on projects tied up in litigation to a consortium of investors led by BlackRock Inc for 17.50 billion rupees ($254.2 million).
Tags: Money, businessNews, Blackrock, BlackRock Inc, HCC, Hindustan Construction Company Ltd HCC


Results of early-stage liver cancer detection using liquid biopsy published in PNAS

Genetron Health Co. Ltd and National Cancer Center/ Cancer Hospital, Chinese Academy of Medical Sciences published the promising results of their liver cancer early screening study using cell free DNA and protein biomarkers. This product for screening HCC in at-risk populations, will be further validated and then available for use. This methodology is expected to be applied in early screening of other cancer types.
Tags: PNAS, HCC, Genetron Health Co Ltd


Crunching the data: New liver cancer subtypes revealed immunologically

Tokyo Medical and Dental University (TMDU) researchers used substantial datasets on liver cancer patients to develop a new classification of hepatocellular carcinoma (HCC) into three distinct subgroups with different genetic, immunological, and clinical features. The findings of HCC subtypes related to metabolic disease, immunosuppression, or mitogenic/stem-cell-like tumors should aid the development of more targeted treatment and promote the fight against this devastating disease.
Tags: HCC, Tokyo Medical and Dental University TMDU


Study shows new emerging role of osteopontin in HCV-related hepatocellular carcinoma

Hepatitis C virus (HCV) infection is the major cause of hepatocellular carcinoma (HCC) and was estimated to be responsible for 745,000 deaths in 2012.
Tags: Health, HCC


Molecular profiling of nonalcoholic fatty liver disease-associated hepatocellular carcinoma using SB transposon mutagenesis [Genetics]

Nonalcoholic fatty liver disease (NAFLD) is the fastest rising cause of hepatocellular carcinoma (HCC) in Western countries; however, the molecular mechanisms that cause NAFLD-HCC remain elusive. To identify molecular drivers of NAFLD-HCC, we performed Sleeping Beauty (SB) transposon mutagenesis screens in liver-specific Pten knockout and in high-fat diet-fed mice, which...
Tags: HCC


Integrative genomic analysis of mouse and human hepatocellular carcinoma [Medical Sciences]

Cancer genomics has enabled the exhaustive molecular characterization of tumors and exposed hepatocellular carcinoma (HCC) as among the most complex cancers. This complexity is paralleled by dozens of mouse models that generate histologically similar tumors but have not been systematically validated at the molecular level. Accurate models of the molecular...
Tags: HCC


5 urban legends about risk-adjusted diagnosis coding

When I talk to medical practices about hierarchical condition category (HCC) and risk-adjusted diagnosis coding, I receive a lot of questions that point to the existence of persistent urban legends! Let’s separate fact from fiction. Urban legend #1: CPT fee-for-service coding will be a distant memory when we switch from volume to value Not anytime soon. Medicare’s newer payment models starting with Medicare Shared Savings Programs (MSSP) and Accountable Care Organizations (ACOs) are built on top...
Tags: Health, Policy, Medicare, Practice Management, CPT, HCC, Medicare Shared Savings Programs MSSP


PSG taps Emkjer and Kaplan as senior advisers

Providence Strategic Growth Partners LLC has named Mark J. Emkjer and Ben Kaplan as senior advisers. Previously, Emkjer was CEO of WebMD Health Services while Kaplan was president and CEO of CashStar. PRESS RELEASE PROVIDENCE, R.I.–(BUSINESS WIRE)–Providence Strategic Growth Capital Partners L.L.C. (“PSG”), an affiliate of Providence Equity Partners L.L.C., a premier global asset management firm with approximately $60 billion in assets under management, today announced that Mark J. Emkjer and Be...
Tags: New York, London, Trends, People, Psg, Providence, University Of Miami, Mark, Ben, Kaplan, HCC, Providence Equity Partners, Blackhawk Network, 3M Corporation, Mark Hastings, Providence Equity Partners L L C


How to eliminate MYCN-positive hepatic cancer stem cells to prevent the recurrence? [Biological Sciences]

I read with great interest the work of Qin et al. (1), in which the authors reveal that acyclic retinoid (ACR) selectively eliminates cancer stem cells (CSCs) of hepatocellular carcinoma (HCC), which highly express MYCN with enhanced Wnt/β-catenin signal pathway. There exist several molecules that are highly expressed in HCC-CSCs,...
Tags: HCC, Qin


Reply to Yoshida: Liver cancer stem cells: Identification and lipid metabolic reprogramming [Biological Sciences]

As a molecular basis by which acyclic retinoid (ACR) prevents recurrence of hepatocellular carcinoma (HCC), we identify MYCN+ liver cancer stem cell (CSC)-like cell serves as a biomarker and therapeutic target to be selectively eliminated by ACR (1). In the Letter by Yoshida (2), the author makes two important comments...
Tags: CSC, Acr, Yoshida, HCC


HMGB1 links chronic liver injury to progenitor responses and hepatocarcinogenesis

Cell death is a key driver of disease progression and carcinogenesis in chronic liver disease (CLD), highlighted by the well-established clinical correlation between hepatocellular death and risk for the development of cirrhosis and hepatocellular carcinoma (HCC). Moreover, hepatocellular death is sufficient to trigger fibrosis and HCC in mice. However, the pathways through which cell death drives CLD progression remain elusive. Here, we tested the hypothesis that high-mobility group box 1 (HMGB...
Tags: HCC, Celine Hernandez, Peter Huebener, Jean-Philippe Pradere, Daniel J. Antoine, Richard A. Friedman, Robert F Schwabe


Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid [Medical Sciences]

Hepatocellular carcinoma (HCC) is a highly lethal cancer that has a high rate of recurrence, in part because of cancer stem cell (CSC)-dependent field cancerization. Acyclic retinoid (ACR) is a synthetic vitamin A-like compound capable of preventing the recurrence of HCC. Here, we performed a genome-wide transcriptome screen and showed...
Tags: CSC, HCC


Vitamin A derivative selectively kills liver cancer stem cells

Acyclic retinoid, an artificial compound derived from vitamin A, has been found to prevent the recurrence of hepatocellular carcinoma (HCC), the most common form of liver cancer. Now, in research published in Proceedings of the National Academy of Sciences, scientists have discovered that the compound targets one class of cancer stem cells, preventing them from giving rise to new tumors.
Tags: Science, National Academy of Sciences, HCC


Study reports decreasing rates of liver transplantation among HCC patients in the U.S.

Patients with hepatocellular carcinoma (HCC) waiting for a liver transplant in the USA are now significantly less likely to receive a new liver than they were around a decade ago. A nationwide study presented today at The International Liver Congress™ 2018 in Paris, France, has confirmed that patients with HCC on the liver transplant list in the USA were more than 50% less likely to receive a transplant in 2014-2016 than they were in 2005-2007.
Tags: Health, Usa, Paris France, HCC


New, sensitive HBV assay may allow earlier detection of hepatocellular carcinoma

Chronic hepatitis B virus (HBV) can progress to cirrhosis and hepatocellular carcinoma (HCC). A study published in The Journal of Molecular Diagnostics describes a new HBV assay that offers advantages over currently used methods because it has the capability to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples.
Tags: Health, HCC, HBV, Journal of Molecular Diagnostics


Screening for hepatocellular carcinoma in patients with hepatitis C-related cirrhosis achieving sustained virological response is likely to be cost effective

A Canadian study suggests that biannual or annual ultrasound screening for HCC is likely to be cost effective after a sustained virological response in those with hepatitis C-related cirrhosis, but not in those with advanced fibrosis without cirrhosis.
Tags: HCC


Personalized T cell therapy shows signs of clinical effectiveness against HBV-related HCC

ILC 2018: HBV DNA integration profile of tumour cells used to guide T cell adoptive immunotherapy in a liver transplant patient with HBsAg-negative HCC metastases in the lungs.
Tags: HCC, HBV


Sensitive new assay detects hepatitis B infection in single liver cells and serum

Chronic hepatitis B virus (HBV) can progress to cirrhosis and hepatocellular carcinoma (HCC). A study published in The Journal of Molecular Diagnostics describes a new HBV assay that offers advantages over currently used methods because it has the capability to detect closed circular DNA (cccDNA) in serum, single cells, and preserved tissue samples. This assay can be used to diagnose HCC at an earlier stage to manage treatment more effectively.
Tags: HCC, HBV, Journal of Molecular Diagnostics


Inhibition of Enhancer of zeste homolog 2 (EZH2) induces natural killer cell-mediated eradication of hepatocellular carcinoma cells [Medical Sciences]

Natural killer (NK) cell-mediated tumor cell eradication could inhibit tumor initiation and progression. However, the factors that regulate NK cell-mediated cancer cell eradication remain unclear. We determined that hepatocellular carcinoma (HCC) cells exhibit transcriptional down-regulation of NK group 2D (NKG2D) ligands and are largely resistant to NK cell-mediated eradication. Because...
Tags: HCC


DNAJB1-PRKACA fusion kinase interacts with {beta}-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma [Medical Sciences]

A segmental deletion resulting in DNAJB1–PRKACA gene fusion is now recognized as the signature genetic event of fibrolamellar hepatocellular carcinoma (FL-HCC), a rare but lethal liver cancer that primarily affects adolescents and young adults. Here we implement CRISPR-Cas9 genome editing and transposon-mediated somatic gene transfer to demonstrate that expression of...
Tags: HCC


Research findings offer prime drug targets to treat rare liver cancer that strikes young people

After years of rigorous research, a team of scientists has identified the genetic engine that drives a rare form of liver cancer. The findings offer prime targets for drugs to treat the usually lethal disease, fibrolamellar hepatocellular carcinoma (FL-HCC), which mainly strikes adolescents and young adults.
Tags: Health, HCC


Nonalcoholic fatty liver disease increases risk of liver, colorectal, and breast cancers

Nonalcoholic fatty liver disease (NAFLD) is one of the more common chronic liver diseases worldwide. It is associated with metabolic syndrome (i.e. insulin resistance and diabetes) and predisposes to cardiovascular disease. In a new study published in the Journal of Hepatology, researchers identified links not only between NAFLD and hepatocellular carcinoma (HCC), which have been well established, but also to cancers outside the liver, including colorectal and breast cancer.
Tags: Science, HCC, Journal of Hepatology