Posts filtered by tags: Nash[x]


How These Columbus Blue Jackets Were Built

At long last, the Columbus Blue Jackets and their fans have something to celebrate that will last a lifetime. The Blue Jackets swept the top-seeded Tampa Bay Lightning out of the first round of the 2019 NHL Playoffs in stunning fashion. The hockey world will remember this for a long time. Hockey is a copycat league. If someone is successful at something, others will try to do the same thing in the hopes they can get a similar result. The question that a lot of people want to know is just ...
Tags: Usa, New York, Washington, Russia, Sport, Gm, Philadelphia, Vancouver, Lake Erie, Hockey, NHL, North America, Columbus, Vegas, Jones, Tampa Bay Lightning

Nash Ensemble at Wigmore Hall: Focus on Sir Harrison Birtwistle

The Nash Ensemble’s annual contemporary music showcase focused on the work of Sir Harrison Birtwistle, a composer with whom the group has enjoyed a long and close association. Three of the six works by Birtwistle performed here were commissioned by the Nash Ensemble, as was Elliott Carter’s Mosaic which, alongside Oliver Knussen’s Study for ‘Metamorphosis’ for solo bassoon, completed a programme was intimate and intricate, somehow both elusive in spirit and richly communicative.
Tags: Religion, Nash, Wigmore Hall, Birtwistle, Elliott Carter, Harrison Birtwistle, Oliver Knussen, Nash Ensemble

A Jeff Bezos-backed startup just inked a deal with $84 billion biotech Gilead to make drugs for a troubling and increasingly common disease (GILD)

Pharmaceutical giant Gilead is teaming up with Silicon Valley startup Insitro to develop better drugs for a quietly emerging disease called NASH. Short for non-alcoholic steatohepatitis, NASH can lead to liver failure and is estimated to affect some 16 million Americans. Insitro is led by the former chief computing officer of Google life-extension spinoff Calico. It has backing from top-notch tech investors like Jeff Bezos and life science firms like Verily.  The three-year deal could be worth...
Tags: Google, Amazon, California, Trends, Silicon Valley, Andreessen Horowitz, Jeff Bezos, Nash, Gilead, Subramanian, Koller, Daphne Koller, Alexa Like, Insitro Insitro, Insitro, Calico How Insitro

Obeticholic acid improves liver fibrosis and other histological features of NASH

A prespecified interim analysis of the ongoing Phase 3 REGENERATE study has confirmed that obeticholic acid (OCA) is effective in the treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis.
Tags: Science, Nash, OCA

Blue Jackets Edge Rangers to Punch Their Playoff Ticket

NEW YORK — Artemi Panarin scored in the shootout and the Columbus Blue Jackets clinched the last playoff spot in the Eastern Conference with a 3-2 victory over the New York Rangers on Friday night. Ryan Dzingel and Panarin scored in the third period for Columbus and Sergei Bobrovsky stopped 25 shots through overtime and all three Rangers attempts in the tiebreaker. Columbus Blue Jackets center Ryan Dzingel (AP Photo/Julio Cortez) The Blue Jackets, 8-2-2 in their past 12 games, sec...
Tags: Usa, New York, Sport, Rangers, Philadelphia, Hockey, NHL, Columbus, New York Rangers, Ottawa, Pittsburgh, MSG, Columbus Blue Jackets, Sergei Bobrovsky, Sergei Belski, Artemi Panarin

Radio Nowhere - Is Anybody Alive Out There?

Radio giant iHeartMedia has filed for a $100 million IPO, even as it just emerges from bankruptcy. William Paterson University Music Business Professor David Philp takes a look at the state of terrestrial radio, its less than graceful handling of the internet's rise, and why it needs to adapt, as radio's core audience ages out while simultaneously switching to other forms of audio entertainment. ______________________________ Guest post by Prof. David Philp of Music Biz 101 I’ve told...
Tags: Music, New York, Congress, North Korea, Pandora, Radio, Nielsen, Howard Stern, Craig, Alexa, Amazon Music, Dawes, Phil Collins, Limbaugh, Nash, GEICO

NGM Bio’s IPO Raises $107M as NASH Drug Continues Clinical Testing

So far this year, NGM Biopharmaceuticals has licensed a drug to Merck, extended a research agreement with that partner, and laid the groundwork to continue mid-stage testing of its wholly-owned lead compound. Now it can add a $107 million IPO to the list.Late Wednesday, NGM sold appoximately 6.7 million shares for $16 apiece, the high end of the price range the South San Francisco company had planned. Those shares are expected to begin trading on the Nasdaq exchange Thursday under the stock sym...
Tags: Deals, Drugs, Ipo, Cancer, San Francisco, Trends, Investing, Merck, Diabetes, Venture Capital, Fda, Type 2 Diabetes, Biotech, Nasdaq, Life Sciences, Clinical Trials

Assault-Weapon Ban Easily Advances in New Zealand Parliament

New Zealand lawmakers on Tuesday advanced legislation that would ban the military-style semi-automatic weapons used in the recent Christchurch mosque shootings, with the support of all but one member of the 120-person parliament.The ban, which applies to semi-automatic rifles and shotguns that can be equipped with detachable magazines capable of holding more than five rounds, must pass two more parliamentary votes before it is signed into law.Police Minister Stuart Nash praised lawmakers Tuesday...
Tags: News, United States, Connecticut, New Zealand, Vermont, Christchurch, Bernie Sanders, Nra, Seymour, Nash, Chris Murphy, Linwood, Stuart Nash, David Seymour, Jacinda Ardern, Ardern

Resolving inflammation in nonalcoholic steatohepatitis

Chronic unresolved inflammation contributes to the development of nonalcoholic steatohepatitis (NASH), a disorder characterized by lipotoxicity, fibrosis, and progressive liver dysfunction. In this issue of the JCI, Han et al. report that maresin 1 (MaR1), a proresolving lipid mediator, mitigates NASH by reprograming macrophages to an antiinflammatory phenotype. Mechanistically, they identified retinoic acid–related orphan receptor α (RORα) as both a target and autocrine regulator of MaR1 produc...
Tags: Nash, Matthew Spite

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

Retinoic acid–related orphan receptor α (RORα) is considered a key regulator of polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis (NASH) pathogenesis. However, hepatic microenvironments that support the function of RORα as a polarity regulator were largely unknown. Here, we identified maresin 1 (MaR1), a docosahexaenoic acid (DHA) metabolite with a function of specialized proresolving mediator, as an endogenous ligand of RORα. MaR1 enhanced the expression ...
Tags: Nash, DHA, Yong-Hyun Han, Kyong-Oh Shin, Ju-Yeon Kim, Daulat B. Khadka, Hyeon-Ji Kim, Yong-Moon Lee, Won-Jea Cho, Ji-Young Cha, Bong-Jin Lee, Mi-Ock Lee

Proposals for Reasonable Technology Regulation and an Internet Court

I have seen the outlines of a regulatory and judicial regime for internet companies that begins to make sense to me. In it, platforms set and are held accountable for their standards and assurances while government is held to account for its job — enforcing the law — with the establishment of internet courts. I have not been a fan of net regulation to date, for reasons I’ll enumerate below. Even Mark Zuckerberg is inviting regulation, though I don’t agree with all his desires (more on t...
Tags: Google, Facebook, Mark Zuckerberg, Europe, Publishing, UK, Fcc, North Korea, China, Germany, Russia, Uncategorized, America, Spain, Atlantic, United States

Bio Roundup: Amyloid Angst, NASH News, Brammer Bagged & More

A week after , the ripple effects are still being felt—and not just by Biogen, which lost billions of dollars in market value in a flash.We’ll kick off this week’s roundup with the aducanumab reaction, which includes plenty of thoughts about the future of the so-called “amyloid hypothesis” and what’s next for another Biogen Alzheimer’s drug that has had mixed results.We’ll also check in on the gene therapy deal spree, the big week in national healthcare policy, and the preparations several com...
Tags: Deals, Obamacare, Trends, Alzheimer's Disease, Affordable Care Act, National, Pfizer, Medicaid, Xarelto, Federal Trade Commission, Life Sciences, Bayer, Clinical Trials, Celgene, Gilead Sciences, Eisai

VC-backed Mirum Pharmaceuticals names Chris Peetz as CEO

Venture-backed Mirum Pharmaceuticals named Chris Peetz as chief executive officer, stepping in for former CEO Mike Grey, who will be in the role of executive chairman of the board. Mirum is backed by investors including NEA, Deerfield Management, Frazier Healthcare Partners, Novo Holdings, Pappas Capital, RiverVest Venture Partners and Rock Springs Capital. Press Release Mirum Pharmaceuticals today announced the appointment of Chris Peetz as chief executive officer. The company’s former CEO, Mik...
Tags: Trends, People, Allergan, St Louis, Chris, Mike, Nash, Washington University, Mirum, Mike Grey, Tobira Therapeutics, Chris Peetz, Jennerex Biotherapeutics Onyx Pharmaceuticals, PFIC, Mirum Pharmaceuticals, ALGS

Heddlu'r De yn darganfod corff ym Mro Morgannwg

Mae Heddlu De Cymru wedi cadarnhau eu bod nhw wedi darganfod corff yn Nash Point ym Mro Morgannwg.
Tags: News, Nash, Heddlu

A Wave Of New Bills Would Ban Abortion Before Most Women Even Know They're Pregnant

While President Donald Trump is banking on the power of inflammatory anti-abortion rhethoric to help him win the White House again, conservative lawmakers in state legislatures across the country are laserfocused on taking the fight to the courts. The road to making abortion illegal in the U.S. again is paved with extreme regulations like so-called “hearbeat bills.”Since January, nearly a dozen states have introduced this type of legislation, which bans abortion as soon as a fetal heartbeat is ...
Tags: Fashion, Music, Minnesota, Supreme Court, California, White House, San Francisco, Georgia, Missouri, Williams, House, Iowa, Ohio, West Coast, Donald Trump, University Of California

Singer Pink adopts pup named Nash while on tour in Tennessee

NASHVILLE, Tenn. (AP) — The pop star Pink added another member to her family this week when she adopted a puppy while in Tennessee on her “Beautiful Trauma” tour. The Tennessean reports the pup has been named Nash, which the star says is short for Nashville. Pink posted a photo on Instagram on Wednesday that […]
Tags: News, Entertainment, Nation, Tennessee, Nashville, Pink, Tenn AP, Nash, Nashville Pink

A startup that claims to reverse diabetes using Silicon Valley's favorite diet just hired a healthcare veteran to lead its expansion

Virta Health, a Silicon Valley startup that fights diabetes using virtual care and the ketogenic diet, is hiring Derek Newell to lead its commercial operations. In interviews with Business Insider, Newell and Virta CEO Sami Inkinen described their plans for the company's future. Newell aims to expand Virta's relationships with insurers, employers, and providers. Newell was formerly the president of healthcare navigation platform Castlight Health. Before that, he founded a digital health startu...
Tags: Apple, US, Trends, Peter Thiel, Silicon Valley, Airbnb, 23andMe, Castlight Health, Zocdoc, Trulia, Venrock, Founders Fund, Derek, Nash, Newell, Rock Health

The 7 Best Russell Crowe Movies

The 7 Best Russell Crowe Movies Russell Crowe is an A-list actor through and through. He is a bonafide Hollywood superstar of the highest order. From gigantic-scale period pieces like Gladiator and Robin Hood to subtle, moving biopics like A Beautiful Mind , what hasn’t Crowe done? He is an Academy Award-winning actor as well as a good-natured talk show guest. He thrives in comedy as much as he does drama and in musicals as much as he does action films. Indeed, his status as a household...
Tags: Amazon, Hollywood, Movies, Washington, Robin Hood, Los Angeles, Article, Thailand, Hugh Jackman, Holland, Russell Crowe, Ryan Gosling, Kevin Spacey, Ridley Scott, Samuel L Jackson, Ron Howard

When Your Teen is Struggling with Anxiety

Since she was 10 years old, Sophie Riegel felt like something was off. “My friends all seemed so carefree. And I had the weight of the world holding me down.” Riegel writes these words in her beautiful, invaluable new book, Don’t Tell Me to Relax: One Teens’ Journey to Survive Anxiety (And How You Can Too). Shortly after, in middle school, Riegel was diagnosed with obsessive-compulsive disorder (OCD), trichotillomania, generalized anxiety disorder and panic disorder. As a parent, you a...
Tags: Psychology, Family, Parenting, Disorders, Self-help, Anxiety, OCD, Generalized Anxiety Disorder, Adolescence, Mental Health And Wellness, Anxiety And Panic, Panic Disorder, Children And Teens, Natasha Daniels, Daniel, Duke University

Coyotes to Retire Doan’s No. 19 Sweater

GLENDALE, Ariz. — Shane Doan holds numerous franchise records, was the epitome of what a captain should be and led the Arizona Coyotes on their deepest playoff run. Those accomplishments only tell part of the story of how he became one of the most revered athletes in Arizona history. Humble to a fault. Deeply connected to the community. Loyal. Generous with his time, whether it was for a cause, casually chatting with a fan or media inquiries following a difficult loss. Always the hardest-w...
Tags: Sport, Arizona, Hockey, NHL, Gary Bettman, Winnipeg, Coyotes, Arizona Coyotes, Winnipeg Jets, Shane Doan, Shane, Nash, GLENDALE Ariz, Dale Hawerchuk, John Marshall, Doan

Bio Roundup: NASH News, Merck Strikes, Digital Tokens & More

The growing epidemic of the fatty liver disease known as NASH, which has no FDA-approved treatment, has led to a frenzied race among drug companies. This week, one company, Intercept Pharmaceuticals, solidified its lead. But how much will being first to the finish line mean when all is said and done?Intercept (NASDAQ: ICPT) reported interim data from a Phase 3 study showing its drug, obeticholic acid (OCA), reduced liver scarring in NASH patients. The results should be enough to support an appr...
Tags: Deals, Startups, Drugs, Cancer, Trends, Investing, Merck, Leukemia, Acne, Inflammatory Bowel Disease, Xerox, Astrazeneca, Fda, National, Pfizer, Abbvie

"I'm Loved on All Sides": An Interview with Yola

The journey by which Yola, the pop/country/folk/soul singer/songwriter from Bristol, UK, has arrived at the launch of her first solo album, Walk Through Fire, has not always been a charmed one by any stretch of the imagination. And yet she's made it. Although it's her debut as a solo artist, overall it's her third album (her first two were made as part of the Bristolian roots group, Phantom Limb). Coming out on the Easy Eye label but with a licensing/distribution deal involving Nonesuch (par...
Tags: Feature, Music, UK, England, New York, London, Lana Del Rey, Beyonce, Interview, Australia, Aretha Franklin, Country, America, Bbc, Soul, Tennessee

$35 Billion Market! Positive Clinical Trial! Yet Shares Are Down?

Here are four reasons Intercept stock is down despite positive data in the company's NASH trial.
Tags: Science, Nash

Intercept Comes in First With Liver Drug, But Race Isn’t Over

The New York-based drugmaker announced Tuesday that its medicine Ocaliva is the first to succeed in a final stage trial for nonalcoholic steatohepatitis (NASH), a liver disease that many drugmakers are targeting for potentially lucrative treatments. The drug may be the only available treatment for NASH for more than a year if it wins FDA approval. Intercept’s drug has side effects, and NASH is shaping up to be an especially tricky market.
Tags: New York, Science, Fda, Nash

The competition's heating up over a $35 billion market to treat NASH, a 'silent disease' millions are living with. But the early results look mixed.

NASH, short for nonalcoholic steatohepatitis, is a type of liver disease in which liver fat builds up in people. It affects an estimated 16 million Americans, but many don't know it until it leads to more serious problems like liver failure and cirrhosis.  Drugmakers are looking at different ways to treat the condition — both early and later as the disease progresses. Some are conducting research to better understand the genetics and other factors associated with NASH. In February, Gilead said...
Tags: China, US, Trends, Earth, Pfizer, Allergan, Jefferies, Business Insider, Trump, Reuters, Nash, Friedman, RBC Capital Markets, Icahn School of Medicine, Gilead, Regeneron

High Price To Pay At The Deadline Plus The Issues With The Anaheim Ducks

from Kevin Paul Dupont of the Boston Globe, - ... A year ago, the lead trade suspect around the NHL was Rick Nash, and Sweeney outbid all suitors with a package that included a first-round draft pick, defensive prospect Ryan Lindgren, along with Matt Beleskey and Ryan Spooner. A year later, from Boston’s perspective, the art of the deal was offloading Spooner and Beleskey, a pair of wingers once thought to be essential offensive elements (they combined for 59 goals while wearing the Spoke...
Tags: Washington, Boston, Sport, Gm, NHL, Ducks, Anaheim Ducks, Murray, Boston Globe, Anaheim, Sweeney, Perry, Ryan Spooner, Matt Beleskey, Rick Nash, Nash

Shook Twins' 'Some Good Lives' Is As Affirming As It Is Magical

None The Shook Twins' fourth full-length release, Some Good Lives, is an incisive album. Identical twins, Katelyn and Laurie Shook, look inward and to their pasts to render an indelible felicity and serenity. Utilizing a full band composed of Barra Brown on drums, Sydney Nash on bass, and Niko Slice on guitar, the grounded instrumentation is the jumpoff for the Shook Twins' hypnotic vocals. Recorded at Hallowed Halls in Portland, Oregon, the album is a canvas portraying thankfulness while payin...
Tags: Music, Review, America, Gop, Portland Oregon, Americana, Music Review, Bernie Sanders, Folk, Sanders, Jedd Beaudoin, Nash, Katelyn, Gregory Alan Isakov, Shook Twins, Barra Brown

The competition's heating up over a $35 billion market to treat NASH, a 'silent disease' millions are living with. But some of the early results don't look promising.

NASH, short for nonalcoholic steatohepatitis, is a type of liver disease in which liver fat builds up in people. It affects an estimated 16 million Americans, but many don't know it until it leads to more serious problems like liver failure and cirrhosis.  Drugmakers are looking at different ways to treat the condition — both early and later as the disease progresses. Some are conducting research to better understand the genetics and other factors associated with NASH. On Monday, Gilead said t...
Tags: US, Trends, Pfizer, Allergan, Business Insider, Trump, Reuters, Nash, Friedman, RBC Capital Markets, Icahn School of Medicine, Gilead, Regeneron, Birnbaum, Alnylam, Scott Friedman

Gilead misses key goal in NASH liver disease trial, shares sink

The study compared the drug, called selonsertib, with a placebo treatment in a trial of nearly 900 patients with compensated cirrhosis, an advanced form of Nonalcoholic Steatohepatitis, or NASH. “While we are disappointed that the STELLAR-4 study did not achieve its primary endpoint, we remain committed to advancing therapies for patients with advanced fibrosis due to NASH, where there is a significant unmet need for effective and well-tolerated treatments," Dr. John McHutchison, Gilead's chief...
Tags: Science, Nash, Gilead, John McHutchison Gilead