Posts filtered by tags: PKD[x]


Using nano “couriers” to deliver PKD drugs to just the right address

The term “mRNA lipid nanoparticle” has become common of late, given the use of Pfizer/BioNTech’s and Moderna’s COVID-19 vaccines make of nanoparticles to carry mRNA into cells. Once inside a cell, the mRNA instructs the cell to make pieces of the proteins that make up the SARS-CoV-2 virus, a process called “translation.” In so doing, […] Find jobs at Careers by Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Tags: Health, Pfizer, Infectious Disease, PKD, Conditions, PA NP, Moderna, CRNA, COVID-19 Coronavirus

The stunning book design behind the new Philip Dick collection

The Folio Society is releasing a limited edition collection of all 118* short stories written by Philip K. Dick — and like a lot of the Folio Society's work, the graphic design is absolutely stunning. Check out the video for more about the process: This limited edition of Philip K. — Read the rest
Tags: Books, Video, Design, News, Book, Designers, Graphic Design, Design Fiction, Philip K Dick, PKD, Folio Society, Science Fiction Design, Philip Dick, Philip K Read

CS Soapbox: The Novel That Inspired Matrix, Inception & WandaVision

BEGIN SLIDESHOW CS Soapbox: The Novel That Inspired Matrix, Inception & WandaVision In 1969 the famed sci-fi author Philip K. Dick wrote what was arguably his most groundbreaking and influential novel, titled Ubik. Since his death in 1982 the late writer’s work has become a cornerstone of the genre (the phrase “Dickian” is common parlance) and has been transformed into numerous classic films and television (Blade Runner, Minority Report, Total Recall, The Man in the High Castle), yet Ubik...
Tags: Christopher Nolan, TV, Movies, Marvel, Disney, Earth, New Jersey, Oscar, Leonardo Dicaprio, TV News, Terry Gilliam, Richard Linklater, Smith, Wanda, Philip K. Dick, Chip

Study describes the diversity of genetic changes that cause inherited kidney disease

A study has described genetic changes in patients with the most common form of hereditary kidney disease that affects an estimated 12.5 million people worldwide. The research, which focussed on Polycystic Kidney Disease (PKD) in Ireland, provides insights into PKD that will assist doctors and patients in the management of this of inherited condition.
Tags: Science, Ireland, PKD

Genetic Discrimination Measures Upheld

In Chapter 11 of the “Canadian Health Law Practice Manual,” Genetics and the Law, Amy Zarzeczny, Tracey M. Bailey and Timothy Caulfield state, One concern that consistently emerges in relation to obtaining genetic information is the worry that an individual may be discriminated against on the basis of his or her genetic make-up and, specifically, on the basis of a predisposition to a certain condition or disease. Discrimination can of course occur on a wide variety of fronts including, but not l...
Tags: Supreme Court, Law, Court, Canada, Bill, Parliament, Ontario, Human Rights Commission, Supreme Court of Canada, Mohammad, HUNTINGTON, Standing Committee, Legislative Assembly, Quebec Court of Appeal, PIPEDA, Karakatsanis

Crystal deposition triggers tubule dilation that accelerates cystogenesis in polycystic kidney disease

The rate of disease progression in autosomal-dominant polycystic kidney disease (ADPKD) has high intrafamilial variability, suggesting that environmental factors may play a role. We hypothesized that a prevalent form of renal insult may accelerate cystic progression and investigated tubular crystal deposition. We report that calcium oxalate (CaOx) crystal deposition led to rapid tubule dilation, activation of PKD-associated signaling pathways, and hypertrophy in tubule segments along the affecte...
Tags: PKD, Thomas Weimbs, Saeed Khan, Vicente E. Torres, Jacob A. Torres, Mina Rezaei, Caroline Broderick, Louis Lin, Xiaofang Wang, Bernd Hoppe, Benjamin D. Cowley Jr, Vincenzo Savica, Ross P. Holmes, Michal Mrug, Holmes Michal Mrug Thomas Weimbs

Parker Drilling Company (PKD) Earnings Call Transcript

PKD earnings call for the period ending March 31, 2019.
Tags: Finance, Article, FBN, PKD, Motley Fool, Fbn/markets, Fox-business/markets, 9dc69b27-99a4-5d52-a1ff-539e0a35b9d7, Parker Drilling Company PKD

Growing evidence: Water as a potential treatment for inherited cause of kidney failure

People with polycystic kidney disease (PKD) could benefit from a moderate increase in water intake, according to new research.
Tags: PKD

Growing evidence: water as a potential treatment for inherited cause of kidney failure

People with polycystic kidney disease (PKD) could benefit from a moderate increase in water intake, according to new research.
Tags: PKD

Structure of the human PKD1-PKD2 complex

Mutations in two genes, PKD1 and PKD2, account for most cases of autosomal dominant polycystic kidney disease, one of the most common monogenetic disorders. Here we report the 3.6-angstrom cryo–electron microscopy structure of truncated human PKD1-PKD2 complex assembled in a 1:3 ratio. PKD1 contains a voltage-gated ion channel (VGIC) fold that interacts with PKD2 to form the domain-swapped, yet noncanonical, transient receptor potential (TRP) channel architecture. The S6 helix in PKD1 is broken ...
Tags: Science, TRP, PKD, VGIC

Rocket Pharma partners with Stanford University to advance FA and PKD gene therapy research

Rocket Pharmaceuticals, Inc., a leading U.S.-based multi-platform gene therapy company, and the Stanford University School of Medicine today announced a strategic collaboration to support the advancement of Fanconi Anemia and Pyruvate Kinase Deficiency gene therapy research.
Tags: Health, Fa, Stanford University, Stanford University School of Medicine, PKD, Rocket Pharma, Rocket Pharmaceuticals Inc, Fanconi Anemia

2018 Porsche 911 GT3 First Test: Beauty Beheld

I stopped counting at 11, any significance to the number a happy coincidence. I always record my conversations with Randy Pobst, held in the doorway of whatever car he’s just lapped. It’s best to get him while everything’s fresh, before anyone says anything that might color his impressions. Today, his impressions were things of beauty. “There’s very little to complain about,” he said. “It behaves so beautifully. The balance is so beautiful. You still have to be a little bit careful not going ...
Tags: Car Performance, First Tests, Amg, Daytona, Randy, Randy Pobst, PDK, PKD, Willow Springs International Raceway

Neither Huxleyed, nor Orwelled: living in the Phildickian dystopia

Political scientist and sf fan Henry Farrell (previously) argues persuasively that the dystopian elements of our everyday life are best viewed through the lens of Philip K Dick (whose books repeatedly depicted a world of constructed realities, whose true nature was obscured by totalitarians, conspiracies, and broken computers) and not Orwell or Huxley, whose computers and systems worked altogether too well to be good parallels for today's janky dystopia. (more…)
Tags: Post, Science Fiction, News, Philip K Dick, Orwell, Botwars, Dystopias, PKD, Huxley, Henry Farrell, Sybil Attacks

Integrated field, laboratory, and theoretical study of PKD spread in a Swiss prealpine river [Ecology]

Proliferative kidney disease (PKD) is a major threat to wild and farmed salmonid populations because of its lethal effect at high water temperatures. Its causative agent, the myxozoan Tetracapsuloides bryosalmonae, has a complex lifecycle exploiting freshwater bryozoans as primary hosts and salmonids as secondary hosts. We carried out an integrated...
Tags: PKD

Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is driven by mutations in PKD1 and PKD2 genes. Recent work suggests that epigenetic modulation of gene expression and protein function may play a role in ADPKD pathogenesis. In this study, we identified SMYD2, a SET and MYND domain protein with lysine methyltransferase activity, as a regulator of renal cyst growth. SMYD2 was upregulated in renal epithelial cells and tissues from Pkd1-knockout mice as well as in ADPKD patients. SMYD2 deficiency...
Tags: PKD, Linda Xiaoyan Li, Lucy X. Fan, Julie Xia Zhou, Jared J. Grantham, James P. Calvet, Julien Sage, Xiaogang Li

Halliburton hires CFO from Houston drilling co.

Houston-based Halliburton Co. (NYSE: HAL) has named a new CFO to fill the position Mark McCollum vacated more than three months ago. Christopher “Chris” Weber will take over the role effective June 22. He currently serves as senior vice president and CFO of Houston-based Parker Drilling Co. (NYSE:PKD), a position he has held for four years. Weber is stepping down from Parker on June 21, and Jon-Al Duplantier, Parker’s senior vice president, chief administrative officer and general counsel,… ...
Tags: Halliburton, Houston, Chris, Weber, Parker, Christopher, Hal, Halliburton Co NYSE, PKD, Mark McCollum, Parker Drilling Co NYSE, Jon Al Duplantier Parker

If Rigs Counts Are Rising, Why Did These Rig Stocks Decline in March?

Despite the improving environment for rigs in the U.S., land drillers took a nosedive in March. Shares of Patterson-UTI Energy (NASDAQ: PTEN) , Nabors Industries (NYSE: NBR) , Parker Drilling (NYSE: PKD) , and Precision Drilling (NYSE: PDS) all declined double digits last month. Wasn't the onshore rig industry supposed to be in the middle of a revival? According to Baker Hughes' weekly rig count survey, active rigs in the field improved 10% in March to a total count of 824. Throughout 201...
Tags: Energy, Finance, Materials, PDS, Baker Hughes, NBR, PKD, PTEN, Getty Images Continue, and Utilities, Tyler Crowe, Nabors Industries NYSE, Patterson UTI Energy NASDAQ, Precision Drilling NYSE, 1aaa6346-186d-11e7-996a-0050569d32b9, NBR Parker Drilling NYSE

The Rig Market Is Looking Up, but These Rig Stocks Dropped in February

Even though there does appear to be a recovery in oil and gas drilling in the United States, shares of land rig companies Precision Drilling (NYSE: PDS) , Nabors Industries (NYSE: NBR) , and Parker Drilling (NYSE: PKD) all ended February down double digits, with Parker dropping 24% after the company announced it was issuing shares and convertible debt.Image source: Getty Images.Let's start with the easy explanation, and that's Parker's share and debt issuances. The company announced that it ...
Tags: Energy, Finance, Materials, United States, Parker, PDS, NBR, PKD, and Utilities, Tyler Crowe, Parker Drilling NYSE, Bd1c6aac-ffe5-11e6-bf23-0050569d32b9, Precision Drilling NYSE, PDS Nabors Industries NYSE

Oil and Gas Stock Roundup: Look Out Below!

While the oil market was rather calm this week, that wasn't the case for a select group of oil stocks. Weak fourth-quarter earnings reports, a dilutive stock offering, and a negative article fueled a big sell-off in some of the sector's weaker players. Leading the way, according to data from S&P Global Market Intelligence, were BP Prudhoe Bay (NYSE: BPT) , QEP Resources (NYSE: QEP) , Denbury Resources (NYSE: DNR) , and Parker Drilling (NYSE: PKD) :BPT Price data by YCharts.Continue reading [...
Tags: Energy, Finance, Materials, Dnr, PKD, and Utilities, Matthew DiLallo, BPT, Prudhoe Bay NYSE, Parker Drilling NYSE, QEP, 327d44d4-fac7-11e6-b015-0050569d4be0

Here’s Why Parker Drilling Company’s Stock Is Plunging Today

Shares of Parker Drilling (NYSE: PKD) sold off on Wednesday morning and were down more than 16% at 10:30 a.m. EST after the company announced two offerings to raise cash.Parker Drilling announced both common stock and mandatory convertible stock offerings. The company priced a 12 million share offering at $2.10 per share, raising about $24 million in net proceeds. On top of that, the company priced a $50 million mandatory convertible preferred stock offering at a 7.5% yield. The company intend...
Tags: Energy, Finance, Materials, PKD, Getty Images Continue, and Utilities, 10% Promise, Matthew DiLallo, 425d443c-f917-11e6-ae97-0050569d4be0, Parker Drilling Company, Parker Drilling NYSE, Parker Drilling

Philip K. Dick’s Electric Dreams on Amazon

Early this morning I saw an email from Dave that pointed me at a giant bundle of happiness. Bryan Cranston Will Bring Philip K. Dick’s Electric Dreams to Series So – let’s go through all the parts of awesomeness of this. First, Philip K. Dick is one of my favorite sci-fi writers. One summer, about five or so years ago, I bought every PKD book I could find in paperback (almost all of them.) I started reading them from first to last. I’ve gotten through about half of them and have sporadically rea...
Tags: Amazon, Trends, Dave, Philip K Dick, Bryan Cranston, Amy, Feld, PKD, BSG, Brian Cranston, Things I Like, Electric Dreams on Amazon, Ronald D Moore Enough

Giving polycystic kidney disease the bump

We launched this campaign at the beginning of October 2016. It's the first time that we've ever had a campaign of this size and scope. It's a European campaign in multiple languages that's coordinated by six of the organizations that represent PKD patients in Europe.
Tags: Health, PKD

Book: The Man in the High Castle

I had a great digital sabbath yesterday with Amy and my friends Dave and Maureen. I had a cold so I took a three hour nap in the middle of the day. For the rest of the day, I sat around in my PJs. I read Philip K. Dick’s The Man in the High Castle. Amy and I loved Season 1 of the Amazon series but struggled with the first episode on Season 2 (I’m sure we’ll fight through it and watch it this week.) Since we got off to a slow start on Season 2, I decided to read the book, which I had resisted rea...
Tags: Amazon, Books, Microsoft, Russia, US, Book, Trends, Dave, Philip K Dick, East Coast, New Yorker, Amy, Maureen, Feld, PKD

Tonight in L.A.: Swans, PAPA, Ken Sharp, Wyatt Blair, John Williams, the Kills, Killswitch Engage, the Lovely Bad Things, Ghost Parade

Los Angeles concerts for Friday: ► Michael Gira and experimental rockers Swans headline the Fonda Theatre in support of the new album “The Glowing Man,” with Baby Dee opening. ► With their album “Kick at the Dust” en route on Sept. 16, PAPA kicks off a run of three straight free Friday night shows at the Bootleg Theater, with Butch Bastard and Marc Baker supporting. ► Ken Sharp celebrates the release of his new album “New Mourning” with a show at the Troubadour, joined by Daisy, Them Guns, Natio...
Tags: Music, Los Angeles, Rays, Preview, Swans, Exodus, John Williams, Castro, National Anthem, Heatwave, Killswitch Engage, Autolux, Bootleg Theater, Papa, Lakeside, Manning

This Week’s Shows: Aug. 29-Sept. 4

Upcoming Los Angeles concerts: Knox Hamilton, Zipper Club, Mondo Drag, Manhattan Murder Mystery, Black Joe Lewis & the Honeybears, Black Uhuru, Ozomatli, the Go-Go’s, Yes, Shy Girls, Paul Bergmann, Aristophanes, Mild High Club, Drake Bell, Jagwar Ma, the Game, Common, Phebe Starr, Tortoise, Holy Shit, Night Years, Inc. No World, Ja Rule, Squirrel Nut Zippers, JR JR, Andy Frasco & the U.N., the Shondes, Night Beats, Kim & the Created, Marshall Tucker Band, John Williams, Killswitch Engage, Swans,...
Tags: Music, Featured, Holy Shit, Los Angeles, Spain, The Zombies, John, Coachella, Martin Luther King, Rays, Preview, Swans, John Williams, Alex, Tortoise, Ashanti

Why Land Drillers Took a Big Hit in July

Image source: Getty Images.What: After some small hopes that oil prices would kick-start drilling were squashed last month, shares of land rig lessors Nabors Industries (NYSE: NBR) , Patterson-UTI Energy (NASDAQ: PTEN) , Precision Drilling (NYSE: PDS) , Unit Corporation (NYSE: UNT)  , and Parker Drilling (NYSE: PKD) all dropped 10% or more in July as oil prices stumbled to the $40-per-barrel range. Continue reading [Author: [email protected] (Tyler Crowe)]
Tags: Energy, Finance, Materials, UNT, PDS, NBR, PKD, PTEN, and Utilities, Tyler Crowe, Nabors Industries NYSE

Deep learning AI "autoencodes" Blade Runner, recreates it so faithfully it gets a takedown notice

Artist and researcher Terence Broad is working on his master's at Goldsmith's computing department; his dissertation involved training neural networks to "autoencode" movies they've been fed. (more…)
Tags: Videos, Post, Science Fiction, Video, Copyfight, UK, Youtube, Scholarship, Ai, Computer Science, Deep Learning, Cgi, War On General Purpose Computing, Goldsmith, PKD

Philip K. Dick Conference 4/29-4/30 in So Cal

On April 29-30 at Cal State Fullerton, fans, scholars, authors, and artists will celebrate surrealist science fiction author Philip K. Dick with an extravaganza of talks, panels, and exhibits! Special guests include Dr. Ursula Heise, Jonathan Lethem, Tim Powers, and James Blaylock. Philip K. Dick Conference 2016
Tags: Post, Science Fiction, Philip K Dick, Cal State Fullerton, PKD, Philip K Dick Conference, Ursula Heise Jonathan Lethem Tim Powers, James Blaylock Philip K Dick

OPEC and Easing Credit Concerns Fuel a Big Energy Stock Rally This Week (CHK, SWN, SM, FELP, PKD)

Image source: Southwestern Energy.News that the upcoming producers' meeting between OPEC and Russia might lead to an agreement to freeze production fueled a big oil price rally earlier this week, with crude breaking through $40 a barrel. That said, the rally did start to fade at the end of the week after more reports surfaced that a deal was no sure thing.Continue reading [Author: [email protected] (Matthew DiLallo)]
Tags: Energy, Russia, Opec, SM, Materials, PKD, SWN, and Utilities, Matthew DiLallo, CHK, FELP, E5763c32-0313-11e6-9f4e-0050569d32b9, Southwestern Energy News

APEX Wins the Philip K. Dick Award

Tonight, in Seattle, I was in the crowd when my novel Apex won the Philip. K Dick Award. Apex is the third and final book of the Nexus Trilogy. Those books have now collectively won the Prometheus Award, the Endeavor Award, been listed on NPR’s list of Best Books of the Year, and been shortlisted for the Arthur C. Clarke Award and the Kitchies Golden Tentacle Award. They also earned me a nomination for the Campbell Award for Best New Author in 2014.To say I’m pleased would be an understatement....
Tags: Arthur C Clarke, Npr, Seattle, Philip K Dick, Adam, Brenda, Marguerite, PKD, Brenda Cooper, Philip K Dick Award Apex, Campbell Award for Best, Doug The